a Biosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute , Tehran University of Medical Sciences , Tehran , Iran.
b Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute , Tehran University of Medical Sciences , Tehran , Iran.
J Drug Target. 2018 Aug;26(7):525-532. doi: 10.1080/1061186X.2017.1387790. Epub 2017 Oct 18.
Fabrication and characterisation of gold nanoparticles (GNPs) through reducing agents and different capped agents are one of their most attractive applications in biomedicine. GNPs are coated using various agents such as carbohydrate, amino acids, peptides and proteins. These capped gold nanoparticles (C-GNPs) are applied for wide different applications including drug delivery in the recent decade and potential treatment and diagnosis in drug delivery systems (DDS). Recent studies have shown that these novel compounds and conjugated-nanoparticles drugs play a key role for the promising cure of high-risk refractory diseases. In addition, it seems that these compounds have a capability for potential treatment of certain cancers. In this review, a well-defined description of C-GNPs and the application of these nanoparticles are discussed. Our study revealed that C-GNPs with anticancer drugs or new compounds could be potentially applied for biomedical usage especially in cancer therapy.
通过还原剂和不同的封端剂制备和表征金纳米粒子（GNPs）是其在生物医学中最具吸引力的应用之一。GNPs 使用各种试剂进行包覆，例如碳水化合物、氨基酸、肽和蛋白质。这些封端的金纳米粒子（C-GNPs）已广泛应用于不同领域，包括近十年来的药物输送以及药物输送系统（DDS）中的潜在治疗和诊断。最近的研究表明，这些新型化合物和共轭纳米粒子药物在治疗高危难治性疾病方面发挥着关键作用。此外，这些化合物似乎具有治疗某些癌症的潜力。在这篇综述中，我们对 C-GNPs 及其应用进行了详细的描述。我们的研究表明，载有抗癌药物或新型化合物的 C-GNPs 可能具有潜在的生物医学用途，特别是在癌症治疗方面。
