感染 2009 年大流行性流感 A(H1N1)病毒的妊娠食蟹猴中 Th1 型辅助性 T 细胞（Th1）：Th2 细胞因子谱和免疫应答不佳。

Dysregulated T-Helper Type 1 (Th1):Th2 Cytokine Profile and Poor Immune Response in Pregnant Ferrets Infected With 2009 Pandemic Influenza A(H1N1) Virus.

机构信息

Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, Tennessee.

Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, South Korea.

出版信息

J Infect Dis. 2018 Jan 17;217(3):438-442. doi: 10.1093/infdis/jix328.

DOI:10.1093/infdis/jix328

PMID:28973317

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5853788/

Abstract

Pregnancy has been associated with severe influenza, an association highlighted during the 2009 pandemic of influenza A(H1N1) virus (A[H1N1]pdm09) infection. To assess the underlying mechanism, we infected pregnant and non-pregnant ferrets with A(H1N1) pdm09 virus. A(H1N1)pdm09-infected pregnant ferrets also had higher levels of inflammatory cytokines in their pulmonary tracts. Systemically, total CD8+ T cell counts and A(H1N1)pdm09-specific B-cell responses in blood were significantly lower in pregnant ferrets. This model predicts that the poorer outcome for pregnant women during the A(H1N1)pdm09 pandemic was due to an elevated level of viral replication and to a cytokine imbalance that led to a less effective immune response.

摘要

妊娠与严重流感有关，这种关联在 2009 年甲型 H1N1 流感病毒（A[H1N1]pdm09）大流行期间得到了强调。为了评估潜在机制，我们用 A(H1N1)pdm09 病毒感染了妊娠和非妊娠雪貂。感染 A(H1N1)pdm09 的妊娠雪貂的肺部炎症细胞因子水平也更高。全身来看，妊娠雪貂血液中的总 CD8+T 细胞计数和针对 A(H1N1)pdm09 的 B 细胞反应显著降低。该模型预测，在 A(H1N1)pdm09 大流行期间，孕妇的不良预后是由于病毒复制水平升高和细胞因子失衡导致免疫反应效果不佳所致。