Desyatova Anastasia, MacTaggart Jason, Kamenskiy Alexey
Department of Surgery, University of Nebraska Medical Center, Omaha, NE, United States.
Department of Surgery, University of Nebraska Medical Center, Omaha, NE, United States.
Acta Biomater. 2017 Dec;64:50-58. doi: 10.1016/j.actbio.2017.09.042. Epub 2017 Sep 30.
Atherosclerotic obstructive disease of the femoropopliteal artery (Peripheral Arterial Disease, PAD) is notorious for high treatment failure rates. Older age and diabetes mellitus (DM) are among the major risk factors for PAD, and both are associated with increased arterial stiffness. Our goal was to develop a constitutive model describing multiaxial arterial stiffening, and use it to portray aging of normal and diabetic human femoropopliteal arteries (FPA). Fresh human FPAs (n=744) were obtained from 13-82-year-old donors. Arteries were tested using planar biaxial extension, and their behavior was modeled with a constitutive relation that included stiffening functions of age. FPA diameter, wall thickness, circumferential, and longitudinal opening angles increased with age, while longitudinal pre-stretch decreased. Diameter and circumferential opening angle did not change with age in subjects with DM. Younger FPAs were more compliant longitudinally but became more isotropic with age. Arteries with DM stiffened significantly faster in the circumferential direction than arteries without DM. Constitutive model accurately portrayed orthotropic stiffening with age of both normal and diabetic arteries. Constitutive description of FPA aging contributes to understanding of arterial pathophysiology and can help improve fidelity of computational models investigating device-artery interaction in PAD repair by providing more personalized arterial properties.
We have analyzed n=744 human femoropopliteal artery (FPA) specimens using biaxial tensile testing to derive constitutive description of FPA aging in diabetic and non-diabetic subjects. The proposed model allows determination of FPA mechanical properties for subjects of any given age in the range of 13-82years. These results contribute to understanding of FPA pathophysiology and can help improve fidelity of computational models investigating device-artery interaction in peripheral arterial disease repair by providing more personalized arterial properties. In addition, they can guide the development of new materials tunable to diabetic and non-diabetic arteries.
股腘动脉粥样硬化性阻塞性疾病（外周动脉疾病，PAD）因治疗失败率高而声名狼藉。高龄和糖尿病（DM）是PAD的主要危险因素，且两者均与动脉僵硬度增加有关。我们的目标是建立一个描述多轴动脉僵硬度增加的本构模型，并用它来描绘正常和糖尿病患者股腘动脉（FPA）的老化情况。从13至82岁的供体获取了744条新鲜人体FPA。使用平面双轴拉伸试验对动脉进行测试，并通过包含年龄僵硬度函数的本构关系对其行为进行建模。FPA直径、壁厚、圆周和纵向开口角度随年龄增加，而纵向预拉伸减小。糖尿病患者的FPA直径和圆周开口角度不随年龄变化。较年轻的FPA在纵向更具顺应性，但随着年龄增长变得更加各向同性。糖尿病动脉在圆周方向上的僵硬度增加明显快于非糖尿病动脉。本构模型准确描绘了正常和糖尿病动脉随年龄的正交各向异性僵硬度增加情况。FPA老化的本构描述有助于理解动脉病理生理学，并通过提供更个性化的动脉特性，有助于提高研究PAD修复中装置 - 动脉相互作用的计算模型的逼真度。
我们使用双轴拉伸试验分析了744条人体股腘动脉（FPA）标本，以得出糖尿病和非糖尿病受试者FPA老化的本构描述。所提出的模型允许确定13至82岁范围内任何给定年龄受试者的FPA力学性能。这些结果有助于理解FPA病理生理学，并通过提供更个性化的动脉特性，有助于提高研究外周动脉疾病修复中装置 - 动脉相互作用的计算模型的逼真度。此外，它们可以指导可调节至糖尿病和非糖尿病动脉的新材料的开发。
