Department of Medical Biotechnology, Yeungnam University, Gyeongsan, South Korea.
Department of Microbiology and Molecular Biology, Chungnam National University, Daejeon, South Korea.
FASEB J. 2018 Feb;32(2):768-781. doi: 10.1096/fj.201700665R. Epub 2018 Jan 4.
Interactions between myoblasts and the surrounding microenvironment led us to explore the role of fibromodulin (FMOD), an extracellular matrix protein, in the maintenance of myoblast stemness and function. Microarray analysis of FMOD myoblasts and in silico studies were used to identify the top most differentially expressed genes in FMOD, and helped establish that FMOD-based regulations of integral membrane protein 2a and clusterin are essential components of the myogenic program. Studies in knockout, obese, and diabetic mouse models helped characterize the operation of a novel FMOD-based regulatory circuit that controls myoblast switching from a myogenic to a lipid accumulation fate. FMOD regulation of myoblasts is an essential part of the myogenic program, and it offers opportunities for the development of therapeutics for the treatment of different muscle diseases.-Lee, E. J., Jan, A. T., Baig, M. H., Ahmad, K., Malik, A., Rabbani, G., Kim, T., Lee, I.-K., Lee, Y. H., Park, S.-Y., Choi, I. Fibromodulin and regulation of the intricate balance between myoblast differentiation to myocytes or adipocyte-like cells.
成肌细胞与周围微环境的相互作用促使我们探索细胞外基质蛋白纤维调蛋白（FMOD）在维持成肌细胞干性和功能中的作用。FMOD 成肌细胞的微阵列分析和计算机模拟研究用于鉴定 FMOD 中差异表达最显著的基因，并帮助确定基于 FMOD 的整联蛋白 2a 和簇蛋白的调节是肌生成程序的重要组成部分。在敲除、肥胖和糖尿病小鼠模型中的研究有助于描述一种新型基于 FMOD 的调控回路的运作，该回路控制成肌细胞从肌生成向脂质积累命运的转换。FMOD 对成肌细胞的调节是肌生成程序的重要组成部分，为治疗不同肌肉疾病的治疗方法的开发提供了机会。-李，E. J.，简，A. T.，拜格，M. H.，艾哈迈德，K.，马利克，A.，拉巴尼，G.，金，T.，李，I.-K.，李，Y. H.，朴，S.-Y.，崔，I. 纤维调蛋白和肌细胞或脂肪细胞样细胞分化过程中微妙平衡的调节。
