Ahmad Khurshid, Shaikh Sibhghatulla, Chun Hee Jin, Ali Shahid, Lim Jeong Ho, Ahmad Syed Sayeed, Lee Eun Ju, Choi Inho
Department of Medical Biotechnology, Yeungnam University, Gyeongsan, 38541, South Korea.
Research Institute of Cell Culture, Yeungnam University, Gyeongsan, 38541, South Korea.
Inflamm Regen. 2023 Nov 27;43(1):58. doi: 10.1186/s41232-023-00308-z.
The regenerative ability of skeletal muscle (SM) in response to damage, injury, or disease is a highly intricate process that involves the coordinated activities of multiple cell types and biomolecular factors. Of these, extracellular matrix (ECM) is considered a fundamental component of SM regenerative ability. This review briefly discusses SM myogenesis and regeneration, the roles played by muscle satellite cells (MSCs), other cells, and ECM components, and the effects of their dysregulations on these processes. In addition, we review the various types of ECM scaffolds and biomaterials used for SM regeneration, their applications, recent advances in ECM scaffold research, and their impacts on tissue engineering and SM regeneration, especially in the context of severe muscle injury, which frequently results in substantial muscle loss and impaired regenerative capacity. This review was undertaken to provide a comprehensive overview of SM myogenesis and regeneration, the stem cells used for muscle regeneration, the significance of ECM in SM regeneration, and to enhance understanding of the essential role of the ECM scaffold during SM regeneration.
骨骼肌（SM）对损伤、伤害或疾病作出反应的再生能力是一个高度复杂的过程，涉及多种细胞类型和生物分子因子的协同活动。其中，细胞外基质（ECM）被认为是SM再生能力的基本组成部分。本综述简要讨论了SM的肌发生和再生、肌肉卫星细胞（MSCs）、其他细胞以及ECM成分所起的作用，以及它们的失调对这些过程的影响。此外，我们还综述了用于SM再生的各种类型的ECM支架和生物材料、它们的应用、ECM支架研究的最新进展，以及它们对组织工程和SM再生的影响，特别是在严重肌肉损伤的情况下，严重肌肉损伤经常导致大量肌肉损失和再生能力受损。进行本综述的目的是全面概述SM的肌发生和再生、用于肌肉再生的干细胞、ECM在SM再生中的意义，并增进对ECM支架在SM再生过程中重要作用的理解。
