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Toward Smarter Lumping and Smarter Splitting: Rethinking Strategies for Sepsis and Acute Respiratory Distress Syndrome Clinical Trial Design.迈向更明智的合并与更明智的拆分:重新思考脓毒症和急性呼吸窘迫综合征临床试验设计策略
Am J Respir Crit Care Med. 2016 Jul 15;194(2):147-55. doi: 10.1164/rccm.201512-2544CP.
2
Effect of Aspirin on Development of ARDS in At-Risk Patients Presenting to the Emergency Department: The LIPS-A Randomized Clinical Trial.阿司匹林对急诊科有ARDS风险患者ARDS发生的影响:LIPS-A随机临床试验
JAMA. 2016 Jun 14;315(22):2406-14. doi: 10.1001/jama.2016.6330.
3
Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries.全球 50 个国家重症监护病房急性呼吸窘迫综合征患者的流行病学、治疗模式和死亡率。
JAMA. 2016 Feb 23;315(8):788-800. doi: 10.1001/jama.2016.0291.
4
Hospital Incidence and Outcomes of the Acute Respiratory Distress Syndrome Using the Kigali Modification of the Berlin Definition.采用柏林定义的基加利修订版评估急性呼吸窘迫综合征的医院发病情况和结局。
Am J Respir Crit Care Med. 2016 Jan 1;193(1):52-9. doi: 10.1164/rccm.201503-0584OC.
5
Ventilator-induced lung injury.呼吸机相关性肺损伤
N Engl J Med. 2013 Nov 28;369(22):2126-36. doi: 10.1056/NEJMra1208707.
6
Pharmacological treatments in ARDS; a state-of-the-art update.急性呼吸窘迫综合征的药物治疗:最新进展。
BMC Med. 2013 Aug 20;11:166. doi: 10.1186/1741-7015-11-166.
7
Functional promoter variants in sphingosine 1-phosphate receptor 3 associate with susceptibility to sepsis-associated acute respiratory distress syndrome.鞘氨醇 1-磷酸受体 3 中的功能性启动子变异与脓毒症相关急性呼吸窘迫综合征易感性相关。
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8
Effect of simvastatin on physiological and biological outcomes in patients undergoing esophagectomy: a randomized placebo-controlled trial.辛伐他汀对接受食管切除术患者生理和生物学结局的影响:一项随机安慰剂对照试验。
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Prone positioning in severe acute respiratory distress syndrome.俯卧位通气治疗严重急性呼吸窘迫综合征。
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Transfusion-related acute lung injury: a clinical review.输血相关急性肺损伤:临床综述。
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急性呼吸窘迫综合征

Acute respiratory distress syndrome .

机构信息

Barts Heart Centre, St Bartholomew's Hospital, London, UK.

National Heart & Lung Institute, Imperial College, London, UK.

出版信息

Clin Med (Lond). 2017 Oct;17(5):439-443. doi: 10.7861/clinmedicine.17-5-439.

DOI:10.7861/clinmedicine.17-5-439
PMID:28974595
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6301945/
Abstract

Acute respiratory distress syndrome is a common cause of acute respiratory failure that is underdiagnosed both inside and outside of intensive care units. Progression to the most severe forms of the syndrome confers a mortality rate greater than 40% and is associated with often severe functional disability and psychological sequelae in survivors. While there are no disease-modifying pharmacotherapies for the syndrome, this progression may be prevented through the institution of quality improvement measures that minimise iatrogenic injury associated with acute severe illness.

摘要

急性呼吸窘迫综合征是急性呼吸衰竭的常见原因,在重症监护病房内外均存在诊断不足的情况。该综合征发展为最严重形式的死亡率超过 40%,并与幸存者经常发生严重的功能障碍和心理后遗症相关。虽然目前尚无针对该综合征的疾病修饰性药物治疗方法,但通过实施质量改进措施,可预防这种进展,这些措施可最大限度地减少与急性重症疾病相关的医源性损伤。