Department of Psychiatry, Seoul St. Mary's Hospital, The Catholic University of Korea, College of Medicine, Seoul, Republic of Korea.
Int J Obes (Lond). 2018 Mar;42(3):327-333. doi: 10.1038/ijo.2017.234. Epub 2017 Oct 4.
BACKGROUND/OBJECTIVES: Decades of research have investigated the association between body mass index (BMI) and depression. Although it has been suggested that obesity lowers the risk of depression in elderly adults, the association of overweight and obesity with depression across age groups remains controversial. Thus, we aimed to investigate how the odds of depression vary between BMI groups in the general population.
SUBJECTS/METHODS: In this study, data were collected from the sixth Korea National Health and Nutrition Examination Survey of 2014 (KNHANES VI; n=7550), and 4932 adults were included in the study sample. We investigated the adjusted association between depression, which was measured by the Patient Health Questionnaire 9 (PHQ-9), and BMI groups (underweight, normal weight, overweight, obese class I, obese classes II and III).
In all adults, after adjusting for sex, age, income and presence of chronic illnesses, overweight had lower odds of depression than normal weight (OR, 0.811; 95% CI, 0.661-0.995), whereas underweight had higher odds of depression than normal-weight subjects (OR, 1.776; 95% CI, 1.241-2.540). Overweight elderly adults had lower odds of depression than normal-weight elderly adults (OR, 0.522, 95% CI, 0.367-0.743), and obese class I elderly adults also had lower odds of depression than normal-weight elderly adults in both men (OR, 0.482, 95% CI, 0.251-0.924) and women (OR, 0.637, 95% CI, 0.418-0.970). Furthermore, in the normal-weight-to-obese class I elderly adults group, we found that an increase of 1 kg m BMI was significantly associated with a decreased prevalence of depression in both men (OR, 0.898, 95% CI, 0.808-0.997) and women (OR, 0.911, 95% CI, 0.844-0.982).
We found that overweight and mild obesity significantly lowered the risk of depression in elderly adults. These findings suggest that mild increases in BMI beyond the normal range may be a protective factor for depression in elderly Korean adults.
背景/目的：几十年来，研究一直致力于探究体重指数（BMI）与抑郁之间的关系。尽管有研究表明肥胖会降低老年人患抑郁症的风险，但超重和肥胖与各年龄段人群抑郁症之间的关联仍存在争议。因此，我们旨在调查一般人群中不同 BMI 组别之间患抑郁症的几率有何差异。
对象/方法：本研究的数据来自于 2014 年韩国第六次全国健康与营养调查（KNHANES VI；n=7550），共有 4932 名成年人纳入研究样本。我们通过患者健康问卷 9（PHQ-9）来调查抑郁症与 BMI 组别（体重不足、正常体重、超重、肥胖 I 级、肥胖 II 级和肥胖 III 级）之间的调整关联。
在所有成年人中，在校正了性别、年龄、收入和慢性病存在情况后，与正常体重相比，超重患抑郁症的几率较低（OR，0.811；95%CI，0.661-0.995），而体重不足患抑郁症的几率较高（OR，1.776；95%CI，1.241-2.540）。与正常体重的老年成年人相比，超重的老年成年人患抑郁症的几率较低（OR，0.522；95%CI，0.367-0.743），而肥胖 I 级的老年成年人无论在男性（OR，0.482；95%CI，0.251-0.924）还是女性（OR，0.637；95%CI，0.418-0.970）中，患抑郁症的几率均较低。此外，在正常体重至肥胖 I 级的老年成年人组别中，我们发现 BMI 每增加 1kg/m2，无论男性（OR，0.898；95%CI，0.808-0.997）还是女性（OR，0.911；95%CI，0.844-0.982），患抑郁症的比例均显著降低。
我们发现超重和轻度肥胖显著降低了老年成年人患抑郁症的风险。这些发现表明，在韩国老年成年人中，BMI 适度超出正常范围可能是预防抑郁症的一个因素。
