Hong Soo Min, Hur Yang-Im
Department of Internal Medicine Department of Family Medicine, Seoul Paik Hospital, Inje University College of Medicine, Seoul, Republic of Korea.
Medicine (Baltimore). 2017 Dec;96(52):e9478. doi: 10.1097/MD.0000000000009478.
Previous studies on the relationship between obesity and depression have produced conflicting results. And only a limited number of studies have been conducted in Asians, and few large-scale nationwide studies have been conducted in Korean populations.We investigated the relationship between obesity and depression in Korean adults using data from a population-based sample from the 2014 Korea National Health and Nutritional Examination Survey (KNHANES) by cross-sectional study.In total, 4026 subjects (1692 men, 2334 women) aged 19 to 69 years participated in the 2014 KNHANES. Current depression was defined as a score ≥10 on the 9-item Patient Health Questionnaire. Height and weight were measured and the body mass index (BMI) was calculated. The participants were asked to complete questionnaires about socio-demographic factors and disease comorbidities, and health-related behaviors. The chi-squared test and multivariate logistic regression analyses were performed to examine the relationship between obesity and depression.Depression was diagnosed in 5.7% of the study participants (3.9% of men, 7.0% of women). According to body weight status, there was a significant difference in the prevalence of depression (underweight: 16.2%, normal weight: 5.5%, overweight: 4.3%, obese [BMI ≥30]: 6.9%). Compared with the normal weight group, the underweight group had a higher adjusted odds ratio (OR) for depression (OR = 3.27, 95% confidence interval [CI]: 1.22, 8.75 in men; OR = 2.00, 95% CI: 1.12, 3.57 in women). Overweight (OR = 0.60, 95% CI: 0.32, 1.13) and obese (OR = 0.62, 95% CI: 0.17, 2.27) men had lower ORs for depression, but this trend was not significant. Compared with normal weight women, obese women had higher adjusted ORs for depression (OR = 1.75, 95% CI: 0.79, 3.88), while overweight women had lower ORs for depression (OR = 0.90, 95% CI: 0.56, 1.45), but these trends were not significant.This study shows differences in the risk of depression depending upon body weight status. Being underweight was correlated with a high risk of developing depression in both men and women, but obesity cannot be ruled out as a risk factor for this condition.
以往关于肥胖与抑郁关系的研究结果相互矛盾。而且在亚洲人中开展的研究数量有限，在韩国人群中进行的大规模全国性研究更是寥寥无几。我们通过横断面研究，利用2014年韩国国民健康与营养检查调查（KNHANES）中基于人群样本的数据，对韩国成年人肥胖与抑郁之间的关系进行了调查。
共有4026名年龄在19至69岁之间的受试者（1692名男性，2334名女性）参与了2014年的KNHANES。当前抑郁被定义为在9项患者健康问卷上的得分≥10分。测量了身高和体重，并计算了体重指数（BMI）。参与者被要求完成关于社会人口学因素、疾病合并症以及健康相关行为的问卷。采用卡方检验和多因素逻辑回归分析来研究肥胖与抑郁之间的关系。
在研究参与者中，5.7%被诊断为抑郁（男性为3.9%，女性为7.0%）。根据体重状况，抑郁患病率存在显著差异（体重过轻：16.2%，正常体重：5.5%，超重：4.3%，肥胖[BMI≥30]：6.9%）。与正常体重组相比，体重过轻组患抑郁的调整优势比（OR）更高（男性：OR = 3.27，95%置信区间[CI]：1.22，8.75；女性：OR = 2.00，95% CI：1.12，3.57）。超重（OR = 0.60，95% CI：0.32，1.13）和肥胖（OR = 0.62，95% CI：0.17，2.27）的男性患抑郁的OR较低，但这种趋势并不显著。与正常体重女性相比，肥胖女性患抑郁的调整OR较高（OR = 1.75，95% CI：0.79，3.88），而超重女性患抑郁的OR较低（OR = 0.90，95% CI：0.56，1.45），但这些趋势也不显著。
这项研究表明，抑郁风险因体重状况而异。体重过轻与男性和女性患抑郁的高风险相关，但肥胖也不能排除是这种情况的一个风险因素。
