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双侧苍白球深部脑刺激治疗难治性眼睑痉挛

Intractable Blepharospasm Treated with Bilateral Pallidal Deep Brain Stimulation.

作者信息

Luthra Nijee S, Mitchell Kyle T, Volz Monica M, Tamir Idit, Starr Phillip A, Ostrem Jill L

机构信息

Department of Neurology, University of California, San Francisco, CA, USA.

Department of Neurosurgery, University of California, San Francisco, CA, USA.

出版信息

Tremor Other Hyperkinet Mov (N Y). 2017 Jul 6;7:472. doi: 10.7916/D8SJ1V9F. eCollection 2017.

DOI:10.7916/D8SJ1V9F
PMID:28975046
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5623756/
Abstract

BACKGROUND

Blepharospasm can be present as an isolated dystonia or in conjunction with other forms of cranial dystonia, causing significant disability.

CASE REPORT

We report a case of a 69-year-old male with craniocervical dystonia, manifesting primarily as incapacitating blepharospasm refractory to medical treatments. He underwent bilateral globus pallidus (GP) deep brain stimulation (DBS) with complete resolution of his blepharospasm and sustained benefit at 12 months postoperatively.

DISCUSSION

This case illustrates successful treatment of blepharospasm with pallidal stimulation. GP-DBS should be considered a reasonable therapeutic option for intractable blepharospasm.

摘要

背景

眼睑痉挛可表现为孤立性肌张力障碍,或与其他形式的颅肌张力障碍合并出现,导致严重残疾。

病例报告

我们报告一例69岁男性患有颅颈肌张力障碍,主要表现为药物治疗无效的致残性眼睑痉挛。他接受了双侧苍白球(GP)深部脑刺激(DBS)治疗,眼睑痉挛完全缓解,术后12个月持续受益。

讨论

该病例说明了苍白球刺激对眼睑痉挛的成功治疗。对于难治性眼睑痉挛,GP-DBS应被视为一种合理的治疗选择。

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Front Neurol. 2021 Mar 29;12:630221. doi: 10.3389/fneur.2021.630221. eCollection 2021.

本文引用的文献

1
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Mov Disord Clin Pract. 2016 Jan 5;3(4):409-411. doi: 10.1002/mdc3.12297. eCollection 2016 Jul-Aug.
2
Subthalamic nucleus deep brain stimulation in isolated dystonia: A 3-year follow-up study.丘脑底核深部脑刺激治疗孤立性肌张力障碍:一项3年随访研究。
Neurology. 2017 Jan 3;88(1):25-35. doi: 10.1212/WNL.0000000000003451. Epub 2016 Nov 30.
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A cross-sectional structured survey of patients receiving botulinum toxin type A treatment for blepharospasm.
一项针对接受A型肉毒杆菌毒素治疗睑痉挛患者的横断面结构化调查。
J Neurol Sci. 2016 Aug 15;367:56-62. doi: 10.1016/j.jns.2016.05.033. Epub 2016 May 16.
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Pallidal stimulation for medically intractable blepharospasm.苍白球刺激术治疗药物难治性睑痉挛。
BMJ Case Rep. 2016 Mar 31;2016:bcr2015214241. doi: 10.1136/bcr-2015-214241.
5
Pallidal neurostimulation in patients with medication-refractory cervical dystonia: a randomised, sham-controlled trial.药物难治性颈肌张力障碍患者的苍白球神经刺激:一项随机、假手术对照试验。
Lancet Neurol. 2014 Sep;13(9):875-84. doi: 10.1016/S1474-4422(14)70143-7. Epub 2014 Aug 7.
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Pallidal deep brain stimulation in the treatment of Meige syndrome.苍白球深部脑刺激治疗 Meige 综合征。
Neurol Neurochir Pol. 2014;48(3):196-9. doi: 10.1016/j.pjnns.2014.05.008. Epub 2014 Jun 6.
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Mixed results for GPi-DBS in the treatment of cranio-facial and cranio-cervical dystonia symptoms.GPi-DBS 治疗头面颈部和颅颈部肌张力障碍症状的效果不一。
J Neurol. 2011 Nov;258(11):2069-74. doi: 10.1007/s00415-011-6075-0. Epub 2011 May 7.
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Long-term clinical outcome in meige syndrome treated with internal pallidum deep brain stimulation.Meige 综合征行脑深部电刺激苍白球内侧部治疗的长期临床疗效。
Mov Disord. 2011 Mar;26(4):691-8. doi: 10.1002/mds.23549. Epub 2011 Feb 10.
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Bilateral pallidal deep brain stimulation in primary Meige syndrome.双侧苍白球深部脑刺激治疗原发性 Meige 综合征。
Parkinsonism Relat Disord. 2011 Feb;17(2):123-5. doi: 10.1016/j.parkreldis.2010.11.013. Epub 2010 Dec 13.
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J Korean Neurosurg Soc. 2010 Aug;48(2):134-8. doi: 10.3340/jkns.2010.48.2.134. Epub 2010 Aug 31.