液体活检在乳腺病变 HPV DNA 诊断中的应用。
Liquid biopsy in the diagnosis of HPV DNA in breast lesions.
机构信息
Department of Experimental, Diagnostic & Specialty Medicine, Alma Mater Studiorum, University of Bologna, 40138, Bologna, Italy.
Center of Applied Biomedical Research (CRBA), S. Orsola-Malpighi Hospital, 40138, Bologna, Italy.
出版信息
Future Microbiol. 2018 Feb;13:187-194. doi: 10.2217/fmb-2017-0145. Epub 2017 Oct 4.
AIM
HPV DNA has never been investigated in nipple discharges (ND) and serum-derived extracellular vesicles, although its presence has been reported in ductal lavage fluids and blood specimens.
MATERIALS & METHODS: We analyzed 50 ND, 22 serum-derived extracellular vesicles as well as 51 pathologic breast tissues for the presence of 16 HPV DNA types.
RESULTS
We show that the presence of HPV DNA in the ND is predictive of HPV DNA-positive breast lesions and that HPV DNA is more represented in intraductal papillomas. We also show the presence of HPV DNA in the serum-derived extracellular vesicles.
CONCLUSION
Our data supports the use of liquid biopsy to detect HPV DNA in breast pathology.
目的
尽管已有研究报道人乳头瘤病毒（HPV）DNA 存在于乳腺导管灌洗液和血液标本中，但乳头溢液（ND）和血清衍生细胞外囊泡中 HPV DNA 的情况仍有待研究。
材料与方法
我们分析了 50 份 ND、22 份血清衍生细胞外囊泡以及 51 份病理性乳腺组织中 16 种 HPV DNA 类型的存在情况。
结果
我们发现 ND 中 HPV DNA 的存在可预测 HPV DNA 阳性的乳腺病变，且 HPV DNA 在乳腺导管内乳头状瘤中更为常见。我们还发现了血清衍生细胞外囊泡中 HPV DNA 的存在。
结论
我们的数据支持使用液体活检来检测乳腺病变中的 HPV DNA。
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