H19 多态性与骨肉瘤风险的关联。

Association between H19 polymorphisms and osteosarcoma risk.

机构信息

Department of Orthopedics, The First People's Hospital of Changzhou, Changzhou, Jiangsu Province, China.

出版信息

Eur Rev Med Pharmacol Sci. 2017 Oct;21(17):3775-3780.

Abstract

OBJECTIVE

The long non-coding RNA (lncRNA) H19, a maternally expressed imprinted gene, has involvement in cancer susceptibility and disease progression. However, the association between H19 polymorphisms and osteosarcoma susceptibility has remained elusive. We designed this case-control study to explore the association between H19 polymorphism and osteosarcoma risk.

PATIENTS AND METHODS

In this study, we genotyped 4 tagger SNPs of the H19 gene in a case-control study including 193 osteosarcoma cases and 393 cancer-free controls.

RESULTS

For the main effect analysis, rs217727 (G>A) was associated with osteosarcoma risk (GA/GG: adjusted OR = 1.51, 95% CI: 1.06-2.17, p = 0.024; AA/GG: adjusted OR = 1.89, 95% CI: 1.23-2.91, p = 0.004; additive model: adjusted OR = 1.35, 95% CI: 1.01-1.80, p = 0.043).

CONCLUSIONS

This finding indicates that rs217727 polymorphism may play a role in genetic susceptibility to the risk of osteosarcoma, which may improve our understanding of the potential contribution of H19 SNPs to cancer pathogenesis.

摘要

目的

长链非编码 RNA（lncRNA）H19 是一种母系表达的印记基因，与癌症易感性和疾病进展有关。然而，H19 多态性与骨肉瘤易感性之间的关联仍不清楚。我们设计了这项病例对照研究，以探讨 H19 多态性与骨肉瘤风险之间的关系。

患者与方法

在这项研究中，我们对 H19 基因的 4 个标签 SNP 进行了基因分型，包括 193 例骨肉瘤病例和 393 例无癌症对照。

结果

对于主要效应分析，rs217727（G>A）与骨肉瘤风险相关（GA/GG：调整后的 OR=1.51，95%CI：1.06-2.17，p=0.024；AA/GG：调整后的 OR=1.89，95%CI：1.23-2.91，p=0.004；加性模型：调整后的 OR=1.35，95%CI：1.01-1.80，p=0.043）。