Reitmaier Sandra, Graichen Friedmar, Shirazi-Adl Aboulfazl, Schmidt Hendrik
1Julius Wolff Institute, Charité-Universitätsmedizin Berlin, Berlin, Germany 2École Polytechnique, Montréal, Canada.
J Bone Joint Surg Am. 2017 Oct 4;99(19):e102. doi: 10.2106/JBJS.17.00172.
Approximately 5,168 large animals (pigs, sheep, goats, and cattle) were used for intervertebral disc research in identified studies published between 1985 and 2016. Most of the reviewed studies revealed a low scientific impact, a lack of sound justifications for the animal models, and a number of deficiencies in the documentation of the animal experimentation. The scientific community should take suitable measures to investigate the presumption that animal models have translational value in intervertebral disc research. Recommendations for future investigations are provided to improve the quality, validity, and usefulness of animal studies for intervertebral disc research. More in vivo studies are warranted to comprehensively evaluate the suitability of animal models in various applications and help place animal models as an integral, complementary part of intervertebral disc research.
在1985年至2016年间发表的已识别研究中，约5168只大型动物（猪、绵羊、山羊和牛）被用于椎间盘研究。大多数综述研究显示科学影响力较低，动物模型缺乏合理依据，动物实验记录存在一些缺陷。科学界应采取适当措施，调查动物模型在椎间盘研究中具有转化价值这一假设。本文提供了未来研究的建议，以提高椎间盘研究动物实验的质量、有效性和实用性。有必要开展更多的体内研究，以全面评估动物模型在各种应用中的适用性，并有助于将动物模型作为椎间盘研究中不可或缺的补充部分。
