Sakai Daisuke
Department of Orthopaedic Surgery, Surgical Science and, Research Center for Regenerative Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
Orthop Clin North Am. 2011 Oct;42(4):555-62, viii-ix. doi: 10.1016/j.ocl.2011.07.005.
The use of stem cell applications has been explored and aimed at regenerating the intervertebral disk. The microenvironment in which cells of the intervertebral disk reside is harsh; however, researchers have reported on many applications for stem cells, including research aimed at defining and stimulating endogenous stem cell populations, methods to induce stem cell differentiation toward intervertebral disk cell phenotype in vivo, and direct transplantation of stem cells into damaged intervertebral disk to promote transplanted site-dependant differentiation. Successful results have been reported, although limitations remain. This article reviews the current status of stem cell research as applied to the intervertebral disk.
干细胞应用已被探索并旨在使椎间盘再生。椎间盘细胞所处的微环境恶劣；然而，研究人员已报道了许多干细胞的应用，包括旨在定义和刺激内源性干细胞群体的研究、在体内诱导干细胞向椎间盘细胞表型分化的方法，以及将干细胞直接移植到受损椎间盘中以促进移植部位依赖性分化。尽管仍存在局限性，但已报道了成功的结果。本文综述了应用于椎间盘的干细胞研究现状。
