WIPI β-螺旋作为支架在自噬中发挥作用，将 STK11/LKB1-AMPK 和 AMPK 相关激酶信号传导联系起来。
WIPI β-propellers function as scaffolds for STK11/LKB1-AMPK and AMPK-related kinase signaling in autophagy.
机构信息
a Department of Molecular Biology, Interfaculty Institute of Cell Biology , Eberhard Karls University Tuebingen , Germany.
b International Max Planck Research School 'From Molecules to Organisms' , Max Planck Institute for Developmental Biology and Eberhard Karls University Tuebingen , Germany.
出版信息
Autophagy. 2018;14(6):1082-1083. doi: 10.1080/15548627.2017.1382784. Epub 2018 Feb 3.
Abstract
The article discusses new findings on the role of the 4 human WIPI proteins at the onset of macroautophagy/autophagy. New insights revealing a circuit scaffold function of WIPI β-propellers that interconnect autophagy signaling control with appropriate autophagosome formation are summarized.
摘要
本文探讨了人类 4 种 WIPI 蛋白在巨自噬/自噬起始中的作用的新发现。总结了新的见解，揭示了 WIPIβ-推进器的电路支架功能，它将自噬信号控制与适当的自噬体形成联系起来。
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本文引用的文献
1
WIPI3 and WIPI4 β-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy.WIPI3 和 WIPI4β-螺旋桨是 LKB1-AMPK-TSC 信号通路在自噬调控中的支架。
Nat Commun. 2017 May 31;8:15637. doi: 10.1038/ncomms15637.
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