Shao Yuqian, Hu Junchao, Li Huihui, Lu Kefeng
Department of Neurosurgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China.
Department of Pathology, West China Second University Hospital, Sichuan University, Chengdu, 610041, China.
Adv Biotechnol (Singap). 2024 Sep 20;2(4):33. doi: 10.1007/s44307-024-00040-w.
Autophagy is a conserved catabolic recycling pathway that can eliminate cytosolic materials to maintain homeostasis and organelle functions. Many studies over the past few decades have demonstrated that abnormal autophagy is associated with a variety of diseases. Protein lipidation plays an important role in the regulation of autophagy by affecting protein trafficking, localization, stability, interactions and signal transduction. Here, we review recent advances in the understanding of the role of lipidation in autophagy, including S-palmitoylation, N-myristoylation, S-prenylation, glycosylphosphatidylinositol (GPI) anchor modification and cholesterylation. We comprehensively review the enzymes and catalytic mechanisms of lipidation and discuss the relationship between lipidation and autophagy, aiming to deepen the understanding of lipidation and promote the discovery of drug targets for the treatment of autophagy-related diseases.
自噬是一种保守的分解代谢循环途径，可清除胞质物质以维持体内平衡和细胞器功能。在过去几十年中，许多研究表明自噬异常与多种疾病相关。蛋白质脂化通过影响蛋白质运输、定位、稳定性、相互作用和信号转导，在自噬调节中发挥重要作用。在此，我们综述了对脂化在自噬中作用的最新认识进展，包括S-棕榈酰化、N-肉豆蔻酰化、S-异戊二烯化、糖基磷脂酰肌醇（GPI）锚定修饰和胆固醇化。我们全面综述了脂化的酶和催化机制，并讨论了脂化与自噬之间的关系，旨在加深对脂化的理解，并促进自噬相关疾病治疗药物靶点的发现。
