Ilic Dusko, Ogilvie Caroline, Noli Laila, Kolundzic Nikola, Khalaf Yacoub
Division of Women's Health, Faculty of Life Sciences and Medicine, King's College London and Assisted Conception Unit, Guy's Hospital, London SE1 9RT, UK.
Genetics Laboratories, Guy's Hospital, London SE1 9RT, UK.
Regen Med. 2017 Sep;12(6):681-691. doi: 10.2217/rme-2017-0052. Epub 2017 Oct 4.
Protocols for successful differentiation of male and female gametes from induced pluripotent stem cells have been published. Although culture of precursor cells in a natural microenvironment remains necessary to achieve terminal differentiation, the creation of human preimplantation embryos from induced pluripotent stem cell-derived gametes is technically feasible. Such embryos could provide a solution to the scarcity of human cleavage-stage embryos donated for research. Here, we discuss current technology, major research-related ethical concerns and propose the norms that would assure the quality and reliability of such embryos.
从诱导多能干细胞成功分化出雄性和雌性配子的方案已经公布。尽管在前体细胞的自然微环境中培养对于实现终末分化仍然是必要的，但利用诱导多能干细胞来源的配子创建人类植入前胚胎在技术上是可行的。这类胚胎可以为用于研究的人类卵裂期胚胎稀缺问题提供一个解决方案。在此，我们讨论当前技术、与研究相关的主要伦理问题，并提出确保这类胚胎质量和可靠性的规范。
