Williams Jessica A, Ding Wen-Xing
Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160, USA.
Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Biol Chem. 2018 Jan 26;399(2):147-178. doi: 10.1515/hsz-2017-0228.
In 2012, we briefly summarized the mechanisms, pathophysiological roles and methods for analyzing mitophagy. As then, the mitophagy field has continued to grow rapidly, and many new molecular mechanisms regulating mitophagy and molecular tools for monitoring mitophagy have been discovered and developed. Therefore, the purpose of this review is to update information regarding these advances in mitophagy while focusing on basic molecular mechanisms of mitophagy in different organisms and its pathophysiological roles. We also discuss the advantage and limitations of current methods to monitor and quantify mitophagy in cultured cells and in vivo mouse tissues.
2012年，我们简要总结了线粒体自噬的机制、病理生理作用及分析方法。自那时起，线粒体自噬领域持续快速发展，发现并开发了许多调控线粒体自噬的新分子机制以及监测线粒体自噬的分子工具。因此，本综述的目的是更新线粒体自噬方面的这些进展，同时聚焦于不同生物体中线粒体自噬的基本分子机制及其病理生理作用。我们还讨论了当前用于监测和量化培养细胞及体内小鼠组织中线粒体自噬的方法的优缺点。
