Koop H, Bothe E, Eissele R, Dionysius J, Arnold R
Dept. of Medicine, Philipps University, Marburg, Federal Republic of Germany.
Res Exp Med (Berl). 1988;188(2):115-21. doi: 10.1007/BF01852267.
Low concentrations of somatostatin and gastrin within or slightly above the range of physiologically circulating levels were perfused in the isolated, vascularly perfused rat stomach preparation. Somatostatin at 10 and 50 pg/ml significantly inhibited acetylcholine-stimulated gastrin secretion by 26% and 45%, respectively, whereas perfusion of 50 and 500 pg/ml exogenous gastrin did not modify gastric somatostatin secretion. Perfusion of somatostatin-antiserum significantly increased gastrin release by 235%. It is concluded that (1) somatostatin is a powerful inhibitor of the gastrin cell under in vitro conditions; the data are in accordance with a concept that endogenous somatostatin could act as a true hormone; (2) the secretory activity of the somatostatin cell is not significantly affected by circulating gastrin.
将低浓度的生长抑素和胃泌素（浓度在生理循环水平范围内或略高于该范围）灌注到离体的、经血管灌注的大鼠胃标本中。10 pg/ml和50 pg/ml的生长抑素分别显著抑制乙酰胆碱刺激的胃泌素分泌26%和45%，而灌注50 pg/ml和500 pg/ml的外源性胃泌素并未改变胃生长抑素的分泌。灌注生长抑素抗血清可使胃泌素释放显著增加235%。结论如下：（1）在体外条件下，生长抑素是胃泌素细胞的强力抑制剂；这些数据符合内源性生长抑素可作为一种真正激素的概念；（2）循环中的胃泌素对生长抑素细胞的分泌活性无显著影响。
