乳酸是脓毒症早期复苏的目标。 - Suppr

Lactate is THE target for early resuscitation in sepsis.

作者信息

Bakker Jan

机构信息

Department of Intensive Care Adults, Erasmus MC University Medical Center - Rotterdam, Netherlands.

Division of Pulmonary, Allergy, and Critical Care Medicine, Columbia University Medical Center - New York, United States.

出版信息

Rev Bras Ter Intensiva. 2017 Apr-Jun;29(2):124-127. doi: 10.5935/0103-507X.20170021.

DOI:10.5935/0103-507X.20170021

PMID:28977252

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5496745/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29b7/5496745/4883c12ce68e/rbti-29-02-0124-g01.jpg

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Lactate is THE target for early resuscitation in sepsis.乳酸是脓毒症早期复苏的目标。

Rev Bras Ter Intensiva. 2017 Apr-Jun;29(2):124-127. doi: 10.5935/0103-507X.20170021.

Sepsis, lactate, and oxygen supply dependence.脓毒症、乳酸与氧供依赖

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Counterpoint: should lactate clearance be substituted for central venous oxygen saturation as goals of early severe sepsis and septic shock therapy? No.反驳观点：在早期严重脓毒症和脓毒性休克治疗中，是否应以乳酸清除率替代中心静脉血氧饱和度作为治疗目标？答案是否定的。

Chest. 2011 Dec;140(6):1408-1413. doi: 10.1378/chest.11-2563.

Guideline promotes early, aggressive sepsis treatment to boost survival.指南提倡早期积极治疗败血症以提高生存率。

JAMA. 2013 Mar 13;309(10):969-70. doi: 10.1001/jama.2013.1295.

Lactate clearance for assessing response to resuscitation in severe sepsis.乳酸清除率评估严重脓毒症复苏反应。

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Why is sepsis resuscitation not more like trauma resuscitation? Should it be?为什么脓毒症复苏不像创伤复苏那样？它应该是吗？

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Sepsis and trauma resuscitation have significant differences.脓毒症和创伤复苏存在显著差异。

J Trauma Acute Care Surg. 2016 Apr;80(4):677. doi: 10.1097/TA.0000000000000972.

Re: Sepsis and trauma resuscitation have significant differences.关于：脓毒症与创伤复苏存在显著差异。

J Trauma Acute Care Surg. 2016 Apr;80(4):677-8. doi: 10.1097/TA.0000000000000973.

Comprehensive Interpretation of Central Venous Oxygen Saturation and Blood Lactate Levels During Resuscitation of Patients With Severe Sepsis and Septic Shock in the Emergency Department.急诊科严重脓毒症和感染性休克患者复苏期间中心静脉血氧饱和度和血乳酸水平的综合解读

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Sepsis Resuscitation: Consensus and Controversies.脓毒症复苏：共识与争议

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Serum lactate poorly predicts central venous oxygen saturation in critically ill patients: a retrospective cohort study.血清乳酸水平对危重症患者中心静脉血氧饱和度的预测价值欠佳：一项回顾性队列研究

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本文引用的文献

The value of blood lactate kinetics in critically ill patients: a systematic review.危重症患者血乳酸动力学的价值：一项系统评价。

Crit Care. 2016 Aug 13;20(1):257. doi: 10.1186/s13054-016-1403-5.

A systematic review and meta-analysis of early goal-directed therapy for septic shock: the ARISE, ProCESS and ProMISe Investigators.一项针对感染性休克早期目标导向治疗的系统评价和荟萃分析：ARISE、ProCESS 和 ProMISe 研究人员。

Intensive Care Med. 2015 Sep;41(9):1549-60. doi: 10.1007/s00134-015-3822-1. Epub 2015 May 8.

Impairment of exogenous lactate clearance in experimental hyperdynamic septic shock is not related to total liver hypoperfusion.实验性高动力型感染性休克中外源性乳酸清除受损与全肝灌注不足无关。

Crit Care. 2015 Apr 22;19(1):188. doi: 10.1186/s13054-015-0928-3.

When to stop septic shock resuscitation: clues from a dynamic perfusion monitoring.何时停止脓毒性休克复苏：来自动态灌注监测的线索。

Ann Intensive Care. 2014 Oct 11;4:30. doi: 10.1186/s13613-014-0030-z. eCollection 2014.

Lactate measurements in sepsis-induced tissue hypoperfusion: results from the Surviving Sepsis Campaign database.脓毒症诱导的组织灌注不足时的乳酸测定：拯救脓毒症运动数据库的结果

Crit Care Med. 2015 Mar;43(3):567-73. doi: 10.1097/CCM.0000000000000742.

Consensus on circulatory shock and hemodynamic monitoring. Task force of the European Society of Intensive Care Medicine.循环休克与血流动力学监测共识。欧洲重症监护医学学会特别工作组。

Intensive Care Med. 2014 Dec;40(12):1795-815. doi: 10.1007/s00134-014-3525-z. Epub 2014 Nov 13.

Fluid overload in patients with severe sepsis and septic shock treated with early goal-directed therapy is associated with increased acute need for fluid-related medical interventions and hospital death.在接受早期目标导向治疗的严重脓毒症和脓毒性休克患者中，液体超负荷与对与液体相关的医疗干预的急性需求增加及医院死亡相关。

Shock. 2015 Jan;43(1):68-73. doi: 10.1097/SHK.0000000000000268.

Prognosis of emergency department patients with suspected infection and intermediate lactate levels: a systematic review.疑似感染且乳酸水平处于中等程度的急诊科患者的预后：一项系统综述

J Crit Care. 2014 Jun;29(3):334-9. doi: 10.1016/j.jcrc.2013.12.017. Epub 2014 Jan 4.

Association between systemic hemodynamics and septic acute kidney injury in critically ill patients: a retrospective observational study.危重症患者全身血流动力学与脓毒症急性肾损伤的相关性：一项回顾性观察研究。

Crit Care. 2013 Nov 29;17(6):R278. doi: 10.1186/cc13133.

Re-thinking resuscitation: leaving blood pressure cosmetics behind and moving forward to permissive hypotension and a tissue perfusion-based approach.重新思考复苏：摒弃血压表面现象，迈向允许性低血压和基于组织灌注的方法。

Crit Care. 2013 Oct 8;17(5):326. doi: 10.1186/cc12727.

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Lactate is THE target for early resuscitation in sepsis.

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