氧化亚铜纳米颗粒通过诱导自噬抑制宫颈癌的生长。
Cuprous oxide nanoparticles inhibit the growth of cervical carcinoma by inducing autophagy.
作者信息
Xia Leilei, Wang Ye, Chen Ya, Yan Jiuqiong, Hao Fan, Su Xiaoling, Zhang Caihong, Xu Mingjuan
机构信息
Department of Obstetrics and Gynaecology, Changhai Hospital, The Second Military Medical University, Shanghai 200433, P.R. China.
Department of Urology, Changhai Hospital, The Second Military Medical University, Shanghai 200433, P.R. China.
出版信息
Oncotarget. 2017 May 15;8(37):61083-61092. doi: 10.18632/oncotarget.17854. eCollection 2017 Sep 22.
Cervical carcinoma is one of the main causes of women's cancer, and substantial side effects from standard treatment including platinum-based chemotherapy limit the options for escalation. In this paper, using cervical cancer cell lines and tumor-bearing mice as models, we report that CONPs could inhibit the proliferation of cancer cells and . Especially CONPs could inhibit tumor growth as cisplatin without weight loss. CONPs could also induce autophagy through AKT/mTOR pathway, which demonstrates that CONPs has the potential clinical applications.
宫颈癌是女性癌症的主要病因之一，包括铂类化疗在内的标准治疗产生的大量副作用限制了强化治疗的选择。在本文中，我们以宫颈癌细胞系和荷瘤小鼠为模型，报告了CONPs可以抑制癌细胞的增殖，特别是CONPs可以像顺铂一样抑制肿瘤生长而不导致体重减轻。CONPs还可以通过AKT/mTOR途径诱导自噬，这表明CONPs具有潜在的临床应用价值。
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