Ren Hanru, Wu Lianghao, Hu Wankun, Ye Xiuzhang, Yu Baoqing
Department of Orthopaedics, Shanghai Pudong Hospital, Fudan University, Pudong Medical Center, Shanghai, China.
Oncotarget. 2017 May 24;8(37):61365-61372. doi: 10.18632/oncotarget.18135. eCollection 2017 Sep 22.
More and more older patients receive the surgery after hip fracture. However, the mortality rate is high. Prognostic nutritional index (PNI) is associated with prognosis in hip fracture patients. In the current study, we proposed a novel prognostic score, named c-reactive protein/PNI ratio (CRP/PNI ratio), for predicting the prognosis for geriatric orthopedic population.
This is a prospective study. Eighty cases of hip fracture surgery in the elderly population were studied to reveal the relationship between the CRP/PNI ratio and the clinicopathological characteristics of the elderly patients. Clinical data included age, sex, weight, length of stay, duration of surgery, comorbidity, and biological data were collected. The primary endpoint was the 1-year mortality rate.
Cox regression and log-rank tests were used to evaluate the correlation of CRP/PNI to the one-year mortality. The one-year mortality rate was low in the patients with a low CRP/PNI ratio ( < 0.001). Univariate and multivariate survival analyses proved that CRP/PNI was an important factor to predict the one-year mortality rate of the geriatric hip fracture surgery patients.
Low CRP/PNI ratio was significantly associated with low one-year mortality rate in older patients after hip fracture surgery.
越来越多的老年患者在髋部骨折后接受手术。然而，死亡率很高。预后营养指数（PNI）与髋部骨折患者的预后相关。在本研究中，我们提出了一种新的预后评分，即C反应蛋白/PNI比值（CRP/PNI比值），用于预测老年骨科人群的预后。
这是一项前瞻性研究。对80例老年髋部骨折手术患者进行研究，以揭示CRP/PNI比值与老年患者临床病理特征之间的关系。收集临床数据，包括年龄、性别、体重、住院时间、手术时长、合并症，并收集生物学数据。主要终点是1年死亡率。
采用Cox回归和对数秩检验评估CRP/PNI与1年死亡率的相关性。CRP/PNI比值低的患者1年死亡率低（<0.001）。单因素和多因素生存分析证明，CRP/PNI是预测老年髋部骨折手术患者1年死亡率的重要因素。
低CRP/PNI比值与老年髋部骨折手术后患者的低1年死亡率显著相关。
