Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity.
作者信息
Kazak Lawrence, Chouchani Edward T, Lu Gina Z, Jedrychowski Mark P, Bare Curtis J, Mina Amir I, Kumari Manju, Zhang Song, Vuckovic Ivan, Laznik-Bogoslavski Dina, Dzeja Petras, Banks Alexander S, Rosen Evan D, Spiegelman Bruce M
出版信息
Cell Metab. 2017 Oct 3;26(4):693. doi: 10.1016/j.cmet.2017.09.007.
Abstract
摘要
相似文献
1
Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity.脂肪细胞肌酸代谢的基因缺失会抑制饮食诱导的产热并导致肥胖。
Cell Metab. 2017 Oct 3;26(4):693. doi: 10.1016/j.cmet.2017.09.007.
2
Adipocyte-specific deletion of Ip6k1 reduces diet-induced obesity by enhancing AMPK-mediated thermogenesis.脂肪细胞特异性缺失Ip6k1通过增强AMPK介导的产热作用减轻饮食诱导的肥胖。
J Clin Invest. 2016 Nov 1;126(11):4273-4288. doi: 10.1172/JCI85510. Epub 2016 Oct 4.
3
Creatine Fuels the Thermic Effect of Feeding.肌酸促进摄食的热效应。
Cell Metab. 2017 Oct 3;26(4):594-595. doi: 10.1016/j.cmet.2017.08.010. Epub 2017 Aug 24.
4
A creatine-driven substrate cycle enhances energy expenditure and thermogenesis in beige fat.肌酸驱动的底物循环增强米色脂肪中的能量消耗和产热作用。
Cell. 2015 Oct 22;163(3):643-55. doi: 10.1016/j.cell.2015.09.035.
5
Tyrphostin AG17 inhibits adipocyte differentiation in vivo and in vitro.Tyrphostin AG17 在体内和体外抑制脂肪细胞分化。
Lipids Health Dis. 2018 May 29;17(1):128. doi: 10.1186/s12944-018-0784-7.
6
A futile approach to fighting obesity?对抗肥胖的徒劳之举？
Cell. 2015 Oct 22;163(3):539-40. doi: 10.1016/j.cell.2015.10.006.
7
UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality.解偶联蛋白1（UCP1）缺失会诱发小鼠肥胖，并消除因处于热中性环境而免受热应激影响的小鼠的饮食诱导产热。
Cell Metab. 2009 Feb;9(2):203-9. doi: 10.1016/j.cmet.2008.12.014.
8
Indole-3-carbinol prevents diet-induced obesity through modulation of multiple genes related to adipogenesis, thermogenesis or inflammation in the visceral adipose tissue of mice.吲哚-3-甲醇通过调节与脂肪生成、生热或炎症相关的多种基因，防止饮食诱导的肥胖。
J Nutr Biochem. 2012 Dec;23(12):1732-9. doi: 10.1016/j.jnutbio.2011.12.005. Epub 2012 May 7.
9
Distinct roles of TRAF6 and TAK1 in the regulation of adipocyte survival, thermogenesis program, and high-fat diet-induced obesity.TRAF6和TAK1在调节脂肪细胞存活、产热程序以及高脂饮食诱导的肥胖中的不同作用。
Oncotarget. 2017 Nov 3;8(68):112565-112583. doi: 10.18632/oncotarget.22575. eCollection 2017 Dec 22.
10
Adaptive facultative diet-induced thermogenesis in wild-type but not in UCP1-ablated mice.适应性兼性饮食诱导的产热在野生型小鼠中存在，而在解偶联蛋白1（UCP1）缺失的小鼠中不存在。
Am J Physiol Endocrinol Metab. 2017 Nov 1;313(5):E515-E527. doi: 10.1152/ajpendo.00097.2017. Epub 2017 Jul 5.
引用本文的文献
1
Adipose tissue ageing: implications for metabolic health and lifespan.脂肪组织衰老：对代谢健康和寿命的影响。
Nat Rev Endocrinol. 2025 Jun 23. doi: 10.1038/s41574-025-01142-8.
2
Thermogenic Adipocytes Promote M2 Macrophage Polarization through CNNM4-Mediated Mg Secretion.产热脂肪细胞通过CNNM4介导的镁分泌促进M2巨噬细胞极化。
Adv Sci (Weinh). 2024 Dec;11(47):e2401140. doi: 10.1002/advs.202401140. Epub 2024 Nov 8.
3
The role of brown adipose tissue in mediating healthful longevity.棕色脂肪组织在介导健康长寿中的作用。
J Cardiovasc Aging. 2024 Apr;4(2). doi: 10.20517/jca.2024.01. Epub 2024 Apr 27.
4
Anti-adipogenesis effect of indole-3-acrylic acid on human preadipocytes and HFD-induced zebrafish.吲哚-3-丙烯酸对人前体脂肪细胞和高脂肪饮食诱导的斑马鱼的抗脂肪生成作用。
Acta Diabetol. 2024 Aug;61(8):975-985. doi: 10.1007/s00592-024-02256-7. Epub 2024 Apr 10.
5
Lipid metabolism dysfunction following symbiont elimination is linked to altered Kennedy pathway homeostasis.共生体消除后的脂质代谢功能障碍与肯尼迪途径稳态改变有关。
iScience. 2023 Jun 12;26(7):107108. doi: 10.1016/j.isci.2023.107108. eCollection 2023 Jul 21.
6
A nitroalkene derivative of salicylate alleviates diet-induced obesity by activating creatine metabolism and non-shivering thermogenesis.水杨酸酯的硝基烯烃衍生物通过激活肌酸代谢和非颤抖性产热来减轻饮食诱导的肥胖。
Res Sq. 2023 Jul 12:rs.3.rs-3101395. doi: 10.21203/rs.3.rs-3101395/v1.
7
Identification of Hub Genes and Biological Mechanisms Associated with Non-Alcoholic Fatty Liver Disease and Triple-Negative Breast Cancer.与非酒精性脂肪性肝病和三阴性乳腺癌相关的枢纽基因及生物学机制的鉴定
Life (Basel). 2023 Apr 12;13(4):998. doi: 10.3390/life13040998.
8
Genetic variants in genes involved in creatine biosynthesis in patients with severe obesity or anorexia nervosa.重度肥胖或神经性厌食症患者中参与肌酸生物合成的基因的遗传变异。
Front Genet. 2023 Apr 10;14:1128133. doi: 10.3389/fgene.2023.1128133. eCollection 2023.
9
Revisiting adipose thermogenesis for delaying aging and age-related diseases: Opportunities and challenges.重新审视脂肪组织产热对延缓衰老和衰老相关疾病的作用：机遇与挑战。
Ageing Res Rev. 2023 Jun;87:101912. doi: 10.1016/j.arr.2023.101912. Epub 2023 Mar 15.
10
Physiological and molecular mechanisms of cold-induced improvements in glucose homeostasis in humans beyond brown adipose tissue.除褐色脂肪组织外，寒冷诱导人体葡萄糖稳态改善的生理和分子机制。
Int J Obes (Lond). 2023 May;47(5):338-347. doi: 10.1038/s41366-023-01270-z. Epub 2023 Feb 11.
Zotero 插件