危重症后抑郁：发病率及危险因素分析
Depression following critical illness: Analysis of incidence and risk factors.
作者信息
Battle Ceri, James Karen, Temblett Paul
机构信息
Ed Major Critical Care Unit, Morriston Hospital, Swansea, UK.
出版信息
J Intensive Care Soc. 2015 May;16(2):105-108. doi: 10.1177/1751143714559904. Epub 2014 Dec 9.
PURPOSE
Depression is common in ICU survivors and is known to negatively affect health-related quality of life. The reported risk factors for depression include increasing age, gender and hospital and ICU length of stay. The aim of this study was to investigate the risk factors for depression in survivors of critical illness.
MATERIALS AND METHODS
Patients attending the ICU Follow-up Clinic completed the Hospital Anxiety and Depression Scale and data were also collected from their medical records. Risk factors investigated included age, gender, Apache II score, ICU length of stay and a diagnosis of sepsis during ICU admission.
RESULTS
A total of 63 patients participated, with 29 (46%) patients suffering with depression. On multivariable logistic regression, the only significant risk factor for depression was sepsis (p < 0.05, odds ratio: 6.8; 95% CI: 1.8-25.8). Age, gender and ICU length of stay were not found to be risk factors for depression.
CONCLUSIONS
There are a number of potential causative factors as to why sepsis would cause long-term depression and this needs further investigation.
目的
抑郁症在重症监护病房（ICU）幸存者中很常见，且已知会对健康相关生活质量产生负面影响。报告的抑郁症风险因素包括年龄增长、性别以及住院和ICU住院时间。本研究的目的是调查危重症幸存者中抑郁症的风险因素。
材料与方法
在ICU随访门诊就诊的患者完成了医院焦虑抑郁量表评估，同时也从他们的病历中收集了数据。调查的风险因素包括年龄、性别、急性生理与慢性健康状况评分系统II（Apache II）评分、ICU住院时间以及在ICU住院期间是否诊断为脓毒症。
结果
共有63名患者参与，其中29名（46%）患者患有抑郁症。多变量逻辑回归分析显示，抑郁症唯一显著的风险因素是脓毒症（p < 0.05，比值比：6.8；95%置信区间：1.8 - 25.8）。年龄、性别和ICU住院时间未被发现是抑郁症的风险因素。
结论
关于脓毒症为何会导致长期抑郁症存在多种潜在的致病因素，这需要进一步研究。
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