Morris Craig, Gray Lewis, Giovannelli Marco
Department of Anaesthesia, Royal Derby Hospital, Derby, UK.
Intensive Care Medicine and Anaesthesia, Royal Derby Hospital, Derby, UK.
J Intensive Care Soc. 2015 Aug;16(3):257-264. doi: 10.1177/1751143715574855. Epub 2015 Mar 18.
A novel synthetic haemabsorption column (Cytosorb™) has recently become commercially available. We describe its use in patients with overwhelming sepsis and consider the experience and evidence supporting its use. While Cytosorb haemabsorption is mechanistically distinct from other extracorporeal therapies in sepsis and appears effective in reducing inflammatory cytokines during sepsis, much of the basic science and clinical benefits remain unclear. Significant interactions including removal of antibiotics may be harmful and require further study. Suggestions for future research and how Cytosorb™ could be incorporated into practice are provided.
一种新型合成血液吸附柱（Cytosorb™）最近已上市。我们描述了其在严重脓毒症患者中的应用，并考量了支持其使用的经验和证据。虽然Cytosorb血液吸附在机制上与脓毒症的其他体外治疗不同，且在脓毒症期间似乎能有效降低炎症细胞因子，但许多基础科学和临床益处仍不明确。包括抗生素清除在内的显著相互作用可能有害，需要进一步研究。本文提供了未来研究的建议以及Cytosorb™如何应用于临床实践的方法。
