de Asua Ignacio, Ciliberti Esteban
Department of Anaesthetics and Intensive Care, Royal Brompton and Harefield NHS Trust, Harefield, Middlesex, UK.
J Intensive Care Soc. 2015 Nov;16(4):316-319. doi: 10.1177/1751143715584383. Epub 2015 Apr 29.
The haemophagocytic syndrome is a unique disease process in which the dysregulation of the patient's immune system leads to an inflammatory storm which rapidly ravages through multiple organ systems, generating life-threatening end-organ dysfunction. Since it usually mimics other conditions frequently encountered in the critical care population - most notably septic shock - its diagnosis is elusive and the condition remains under-recognized and under-reported. We present a concise review of the pathophysiology and clinical features of the heamophagocytic syndrome and discuss the main diagnostic and therapeutic issues relevant to the management of this condition in the critically ill patient. Increasing awareness about the haemophagocytic syndrome amongst intensive care physicians will facilitate earlier recognition and timely management.
噬血细胞综合征是一种独特的疾病过程，其中患者免疫系统的失调会引发炎症风暴，迅速侵袭多个器官系统，导致危及生命的终末器官功能障碍。由于它通常类似于重症监护人群中常见的其他病症——最显著的是脓毒性休克——其诊断难以捉摸，该病症仍未得到充分认识和报告。我们简要综述了噬血细胞综合征的病理生理学和临床特征，并讨论了与危重症患者该病症管理相关的主要诊断和治疗问题。提高重症监护医生对噬血细胞综合征的认识将有助于早期识别和及时管理。
