Grover Chander, Kharghoria Geetali, Daulatabad Deepashree, Bhattacharya Sambit N
Department of Dermatology and STD, University College of Medical Sciences and GTB Hospital, New Delhi, India.
Indian Dermatol Online J. 2017 Sep-Oct;8(5):350-351. doi: 10.4103/idoj.IDOJ_333_16.
Nicolau syndrome (Embolia cutis medicamentosa) is a rare complication following parenteral administration of a drug. It has been reported in association with intramuscular, subcutaneous, intravenous and intra-articular injections. However, Nicolau syndrome following intramatricial injection has not been described to the best of our knowledge. We report the case of an 18-year-old male who developed this complication following 7 session of intramatricial injection. The patient was started on broad spectrum antibiotic coverage, vasodilator therapy, analgesics, and daily dressing. On day 21, the symptoms completely resolved with return of normal color of the digit. The case is being reported to make dermatologists aware of the possibility of Nicolau syndrome following intramatricial injection of triamcinolone acetonide.
尼科劳综合征（药物性皮肤栓塞）是药物经胃肠外给药后一种罕见的并发症。已有报道称其与肌内、皮下、静脉内及关节内注射有关。然而，据我们所知，尚未有关于基质内注射后发生尼科劳综合征的描述。我们报告一例18岁男性在接受7次基质内注射后出现该并发症的病例。患者开始接受广谱抗生素治疗、血管舒张剂治疗、镇痛治疗及每日换药。在第21天，症状完全缓解，手指颜色恢复正常。报告该病例是为了让皮肤科医生意识到在基质内注射曲安奈德后发生尼科劳综合征的可能性。
