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关节卸载植入系统植入后出现严重金属中毒及血清铬升高。

Severe metallosis and elevated chromium in serum following implantation of the joint unloading implant system.

作者信息

Wolff Matthias, Haasper Carl, Zahar Akos, Gauck Christian, Gehrke Thorsten, Citak Mustafa

机构信息

Department of Orthopaedic Surgery, Helios ENDO-Klinik Hamburg, Holstenstrasse 2, 22767, Hamburg, Germany.

Department of Orthopaedic Surgery, AMEOS Klinikum Seepark Geestland, Geestland, Germany.

出版信息

Arch Orthop Trauma Surg. 2017 Dec;137(12):1751-1754. doi: 10.1007/s00402-017-2813-9. Epub 2017 Oct 4.

DOI:10.1007/s00402-017-2813-9
PMID:28980106
Abstract

In recent years, the minimally invasive joint-preserving implant system has been developed. The main goal of this device is to unload the medial knee compartment without affecting the lateral compartment. The current authors describe a severe metallosis and elevated chromium in serum following implantation of the joint unloading implant system of a 50-year-old male patient, presented to our hospital 3 years after implantation of a KineSpring System into his left knee due to unicompartmental medial osteoarthritis (OA) in an external hospital. Radiographs showed radiological signs for loosening of the screws in the tibia and a progressive OA on the medial and patellofemoral compartments. Revision surgery with removing of the unloading device was performed at our hospital. The intraoperative situs presented a severe metallosis around the device. Five days after revision surgery, the laboratory parameters revealed an elevated value for chromium in serum, while nickel and cobalt values in serum were normal. Reliable clinical data about the long-term results of the KineSpring System is desperately needed. Further studies are warranted to work out the effects of cobalt and chromium levels and further side effects following the implantation of the extra-articular absorber system.

摘要

近年来,微创保关节植入系统得到了发展。该装置的主要目标是减轻膝关节内侧间室的负荷,而不影响外侧间室。本文作者描述了一名50岁男性患者在植入关节卸载植入系统后出现严重金属中毒及血清铬升高的情况。该患者因单髁内侧骨关节炎(OA)在外部医院左膝植入KineSpring系统3年后前来我院就诊。X线片显示胫骨螺钉有松动的影像学征象,内侧和髌股间室有进行性OA。我院对其进行了取出卸载装置的翻修手术。术中可见装置周围有严重的金属中毒。翻修手术后5天,实验室检查参数显示血清铬值升高,而血清镍和钴值正常。目前迫切需要关于KineSpring系统长期结果的可靠临床数据。有必要进一步开展研究,以明确关节外吸收系统植入后钴和铬水平的影响以及其他副作用。

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Haemodynamic instability during hip prothesis removal due to metallosis: An acute chrome/cobalt intoxication? A case report.金属沉着病导致髋关节假体取出术中的血流动力学不稳定:急性铬/钴中毒?一例报告。
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