Rubin K, Tingström A, Hansson G K, Larsson E, Rönnstrand L, Klareskog L, Claesson-Welsh L, Heldin C H, Fellström B, Terracio L
Department of Medical and Physiological Chemistry, University of Uppsala, Sweden.
Lancet. 1988 Jun 18;1(8599):1353-6. doi: 10.1016/s0140-6736(88)92177-0.
Expression of B-type receptors for platelet-derived growth factor (PDGF) in frozen sections of blood vessels from tissues affected by abnormal vascular cell proliferation was investigated by immunohistochemical techniques and compared with expression of these receptors in blood vessels of normal tissues. Receptors were not expressed, or expressed at low levels, in vessels of normal tissues. In contrast, a pronounced expression of PDGF B-type receptors was seen on vascular smooth muscle cells in atherosclerotic plaques, rejected kidneys, and chronic synovitis. These observations suggest induction of PDGF B-type receptors on vascular smooth muscle cells in inflamed tissues, which would render such cells responsive to growth stimulation by PDGF released from captured platelets, or produced locally (eg, by inflammatory cells or smooth muscle cells). Autocrine or paracrine stimulation of cell growth caused by the effect of PDGF on cells with induced receptors may be important in the formation of the proliferative lesions found in atherosclerosis and in certain forms of chronic inflammation.
采用免疫组化技术研究了血小板衍生生长因子（PDGF）B型受体在血管异常细胞增殖所累及组织的血管冰冻切片中的表达情况，并与这些受体在正常组织血管中的表达进行了比较。在正常组织的血管中，受体不表达或低水平表达。相比之下，在动脉粥样硬化斑块、移植排斥的肾脏以及慢性滑膜炎中，血管平滑肌细胞上可见PDGF B型受体的显著表达。这些观察结果提示，炎症组织中的血管平滑肌细胞上诱导产生了PDGF B型受体，这会使这些细胞对捕获的血小板释放的或局部产生的（如由炎症细胞或平滑肌细胞产生的）PDGF的生长刺激产生反应。PDGF对具有诱导受体的细胞的作用所引起的细胞生长的自分泌或旁分泌刺激，可能在动脉粥样硬化和某些形式的慢性炎症中发现的增殖性病变的形成中起重要作用。
