Kupfer Tom, Lehmann Joerg, Butler Duncan J, Ramanathan Ganesan, Bailey Tracy E, Franich Rick D
School of Science, RMIT University, Melbourne, Vic., Australia.
Radiation Oncology Centre, Austin Health, Heidelberg, Vic., Australia.
J Appl Clin Med Phys. 2017 Nov;18(6):206-217. doi: 10.1002/acm2.12185. Epub 2017 Oct 4.
This study investigates a large-area plane-parallel ionization chamber (LAC) for measurements of dose-area product in water (DAP ) in megavoltage (MV) photon fields.
Uniformity of electrode separation of the LAC (PTW34070 Bragg Peak Chamber, sensitive volume diameter: 8.16 cm) was measured using high-resolution microCT. Signal dependence on angle α of beam incidence for square 6 MV fields of side length s = 20 cm and 1 cm was measured in air. Polarity and recombination effects were characterized in 6, 10, and 18 MV photons fields. To assess the lateral setup tolerance, scanned LAC profiles of a 1 × 1 cm field were acquired. A 6 MV calibration coefficient, N , was determined in a field collimated by a 5 cm diameter stereotactic cone with known DAP . Additional calibrations in 10 × 10 cm fields at 6, 10, and 18 MV were performed.
Electrode separation is uniform and agrees with specifications. Volume-averaging leads to a signal increase proportional to ~1/cos(α) in small fields. Correction factors for polarity and recombination range between 0.9986 to 0.9996 and 1.0007 to 1.0024, respectively. Off-axis displacement by up to 0.5 cm did not change the measured signal in a 1 × 1 cm field. N was 163.7 mGy cm nC and differs by +3.0% from the coefficient derived in the 10 × 10 cm 6 MV field. Response in 10 and 18 MV fields increased by 1.0% and 2.7% compared to 6 MV.
The LAC requires only small correction factors for DAP measurements and shows little energy dependence. Lateral setup errors of 0.5 cm are tolerated in 1 × 1 cm fields, but beam incidence must be kept as close to normal as possible. Calibration in 10 × 10 fields is not recommended because of the LAC's over-response. The accuracy of relative point-dose measurements in the field's periphery is an important limiting factor for the accuracy of DAP measurements.
本研究调查一种大面积平行板电离室(LAC),用于测量兆伏(MV)光子束在水中的剂量面积乘积(DAP)。
使用高分辨率微型计算机断层扫描(microCT)测量LAC(PTW34070布拉格峰电离室,灵敏体积直径:8.16 cm)电极间距的均匀性。在空气中测量边长s = 20 cm和1 cm的方形6 MV射野的信号随束入射角度α的变化。在6、10和18 MV光子束射野中表征极性和复合效应。为评估横向摆位容差,获取1×1 cm射野的扫描LAC剖面。在由已知DAP的直径5 cm立体定向锥形准直器准直的射野中确定6 MV校准系数N。在6、10和18 MV的10×10 cm射野中进行额外校准。
电极间距均匀,符合规格要求。体积平均导致小射野中信号增加与~1/cos(α)成正比。极性和复合的校正因子分别在0.9986至0.9996和1.0007至1.0024之间。在1×1 cm射野中,离轴位移达0.5 cm时测量信号不变。N为163.7 mGy cm/nC,比在10×10 cm 6 MV射野中导出的系数高3.0%。与6 MV相比,10和18 MV射野中的响应分别增加1.0%和2.7%。
LAC进行DAP测量时仅需较小的校正因子,且能量依赖性小。在1×1 cm射野中可容忍0.5 cm的横向摆位误差,但束入射必须尽可能接近垂直。由于LAC的过度响应,不建议在10×10射野中进行校准。射野周边相对点剂量测量的准确性是DAP测量准确性的重要限制因素。