Freychet L, Rizkalla S W, Desplanque N, Basdevant A, Zirinis P, Tchobroutsky G, Slama G
Department of Diabetes, Hôtel-Dieu Hospital, Paris, France.
Lancet. 1988 Jun 18;1(8599):1364-6. doi: 10.1016/s0140-6736(88)92181-2.
Glucagon in solution with a surfactant (deoxycholic acid 1% w/v) was administered by intranasal spray to 6 healthy fasting subjects and 6 insulin-dependent diabetics with insulin-induced hypoglycaemia. In the normal subjects, intranasal glucagon increased plasma glucose levels, with a dose-response effect. In the diabetic patients, plasma glucose levels showed a mean increase of 100% above nadir values in approximately 26 min in response to 7.5 mg intranasal glucagon; hypoglycaemic symptoms were relieved within about 7 min. These results suggest that intranasal glucagon is effective and may represent an alternative to parenteral glucagon or glucose or to oral sugar as the first-line treatment of hypoglycaemic episodes in insulin-dependent diabetics.
将含有表面活性剂（脱氧胆酸1% w/v）的胰高血糖素通过鼻内喷雾给予6名健康空腹受试者和6名因胰岛素导致低血糖的胰岛素依赖型糖尿病患者。在正常受试者中，鼻内给予胰高血糖素可使血浆葡萄糖水平升高，呈剂量反应效应。在糖尿病患者中，给予7.5毫克鼻内胰高血糖素后，血浆葡萄糖水平在约26分钟内平均比最低点值升高100%；低血糖症状在约7分钟内得到缓解。这些结果表明，鼻内胰高血糖素是有效的，可能是胰岛素依赖型糖尿病患者低血糖发作一线治疗中肠外胰高血糖素、葡萄糖或口服糖的替代方法。
