Institute of Biotechnology, The Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan 030006, China.
College of Life Science, Shanxi University, Taiyuan 030006, China.
Int J Mol Sci. 2023 Apr 10;24(8):6978. doi: 10.3390/ijms24086978.
Diabetes is the most common metabolic disorder, with an extremely serious effect on health systems worldwide. It has become a severe, chronic, non-communicable disease after cardio-cerebrovascular diseases. Currently, 90% of diabetic patients suffer from type 2 diabetes. Hyperglycemia is the main hallmark of diabetes. The function of pancreatic cells gradually declines before the onset of clinical hyperglycemia. Understanding the molecular processes involved in the development of diabetes can provide clinical care with much-needed updates. This review provides the current global state of diabetes, the mechanisms involved in glucose homeostasis and diabetic insulin resistance, and the long-chain non-coding RNA (lncRNA) associated with diabetes.
糖尿病是最常见的代谢紊乱疾病，对全球卫生系统造成了极其严重的影响。它已成为继心脑血管疾病之后的一种严重的、慢性的、非传染性疾病。目前，90%的糖尿病患者患有 2 型糖尿病。高血糖是糖尿病的主要特征。在临床高血糖出现之前，胰腺细胞的功能逐渐下降。了解糖尿病发展过程中涉及的分子过程，可以为临床治疗提供急需的更新。本综述介绍了当前全球糖尿病的状况、葡萄糖内稳态和糖尿病胰岛素抵抗涉及的机制，以及与糖尿病相关的长链非编码 RNA（lncRNA）。
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