Hestiantoro A, Wiwie M, Shadrina A, Ibrahim N, Purba J S
a Department of Obstetrics and Gynecology , Reproductive Immunoendocrinology Division, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital , Jakarta , Indonesia.
b Department of Psychiatry, Faculty of Medicine Universitas Indonesia , Cipto Mangunkusumo Hospital , Jakarta , Indonesia.
Climacteric. 2017 Dec;20(6):577-582. doi: 10.1080/13697137.2017.1377696. Epub 2017 Oct 5.
To determine the role of anthropometric measurement, menopausal symptoms and biochemical marker changes as screening methods for mild cognitive impairment (MCI) in postmenopausal women Methods: A cross-sectional study included 282 postmenopausal women in Jakarta, further classified into two groups, with and without MCI. Some related variables such as age, body mass index (BMI), duration of menopause, vasomotor symptoms, hormone levels such as follicle stimulating hormone (FSH), luteinizing hormone, leptin, estradiol, and cognitive status, were assessed and analyzed.
The FSH levels significantly correlated with MCI incidence (p = 0.018), along with the ratio of FSH/estradiol levels (p = 0.029) and ratio of FSH/soluble leptin receptor (p = 0.011), while other variables did not. By multivariate analysis, the ratio of FSH/estradiol was known as the most significant factor with a probability of having MCI in menopausal women of 1.15. Using the ROC curve, the threshold of the ratio FSH/estradiol to predict MCI was 1.94, with sensitivity 66.5% and specificity 46.8%.
The ratio of FSH to estradiol (>1.94) can be used as a screening method for the occurrence of MCI in postmenopausal women.
确定人体测量、更年期症状和生化标志物变化作为绝经后女性轻度认知障碍（MCI）筛查方法的作用。方法：一项横断面研究纳入了雅加达的282名绝经后女性，进一步分为两组，即患有MCI和未患有MCI的女性。对一些相关变量进行了评估和分析，如年龄、体重指数（BMI）、绝经持续时间、血管舒缩症状、激素水平，如促卵泡生成素（FSH）、促黄体生成素、瘦素、雌二醇以及认知状态。
FSH水平与MCI发病率显著相关（p = 0.018），FSH/雌二醇水平比值（p = 0.029）以及FSH/可溶性瘦素受体比值（p = 0.011）也与之相关，而其他变量则无此关联。通过多变量分析，FSH/雌二醇比值被认为是最显著的因素，绝经后女性患MCI的概率为1.15。使用ROC曲线，预测MCI的FSH/雌二醇比值阈值为1.94，敏感性为66.5%，特异性为46.8%。
FSH与雌二醇的比值（>1.94）可作为绝经后女性MCI发生情况的筛查方法。
