11C-胆碱正电子发射断层显像引导的立体定向体部放射治疗寡转移前列腺癌淋巴结转移灶
11C-Choline-Pet Guided Stereotactic Body Radiation Therapy for Lymph Node Metastases in Oligometastatic Prostate Cancer.
作者信息
Franzese Ciro, Lopci Egesta, Di Brina Lucia, D'Agostino Giuseppe Roberto, Navarria Pierina, Mancosu Pietro, Tomatis Stefano, Chiti Arturo, Scorsetti Marta
机构信息
a Radiotherapy and Radiosurgery , Humanitas Clinical and Research Center , Via Manzoni Rozzano ( Milano ) - Italy.
b Nuclear Medicine , Humanitas Clinical and Research Center , Via Manzoni Rozzano ( Milano ) - Italy.
出版信息
Cancer Invest. 2017 Oct 21;35(9):586-593. doi: 10.1080/07357907.2017.1375116. Epub 2017 Oct 5.
INTRODUCTION
aim is outcome of 11C-Choline-PET guided SBRT on lymph node metastases.
MATERIALS AND METHODS
patients with 1 - 4 lymph node metastases detected by 11C-choline-PET were treated with SBRT. Toxicity, treated metastases control and Progression Free Survival were computed.
RESULTS
twenty-six patients, 38 lymph node metastases were irradiated. No grade ≥ 2 toxicity. Median PSA-nadir after RT was 1.02 ng/mL. Post-treatment 11C-Choline-PET showed metabolic complete response in 17 metastases (44,7%), partial response in 9 metastases (38%).
CONCLUSION
SBRT is effective and safe for lymph node metastases. PET is important in identification of gross tumor and evaluation of the response.
引言
目的是探讨11C-胆碱正电子发射断层扫描（PET）引导下的立体定向体部放疗（SBRT）对淋巴结转移灶的治疗效果。
材料与方法
对11C-胆碱PET检测出1 - 4个淋巴结转移灶的患者进行SBRT治疗。计算毒性反应、治疗后转移灶控制情况及无进展生存期。
结果
26例患者，共38个淋巴结转移灶接受了放疗。无≥2级毒性反应。放疗后前列腺特异抗原（PSA）最低值中位数为1.02 ng/mL。治疗后11C-胆碱PET显示17个转移灶（44.7%）代谢完全缓解，9个转移灶（38%）部分缓解。
结论
SBRT对淋巴结转移灶有效且安全。PET在大体肿瘤识别及疗效评估中具有重要作用。
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