转录程序在自噬调控中的新作用。
Emerging roles of transcriptional programs in autophagy regulation.
作者信息
Sakamaki Jun-Ichi, Long Jaclyn S, New Maria, Van Acker Tim, Tooze Sharon A, Ryan Kevin M
机构信息
a Cancer Research UK Beatson Institute, Garscube Estate , Glasgow , UK.
b Molecular Cell Biology of Autophagy , Francis Crick Institute , London , UK.
出版信息
Transcription. 2018;9(2):131-136. doi: 10.1080/21541264.2017.1372045. Epub 2017 Nov 3.
Abstract
Autophagy is an essential cellular process that degrades cytoplasmic organelles and components. Precise control of autophagic activity is achieved by context-dependent signaling pathways. Recent studies have highlighted the involvement of transcriptional programs during autophagic responses to various signals. Here, we summarize the current understanding of the transcriptional regulation of autophagy.
摘要
自噬是一种重要的细胞过程，可降解细胞质细胞器和成分。自噬活性的精确控制是通过依赖于环境的信号通路实现的。最近的研究强调了转录程序在对各种信号的自噬反应中的作用。在这里，我们总结了目前对自噬转录调控的理解。
相似文献
1
Emerging roles of transcriptional programs in autophagy regulation.转录程序在自噬调控中的新作用。
Transcription. 2018;9(2):131-136. doi: 10.1080/21541264.2017.1372045. Epub 2017 Nov 3.
2
Regulation of the transcription factor EB-PGC1α axis by beclin-1 controls mitochondrial quality and cardiomyocyte death under stress.贝clin-1对转录因子EB-PGC1α轴的调控在应激状态下控制线粒体质量和心肌细胞死亡。
Mol Cell Biol. 2015 Mar;35(6):956-76. doi: 10.1128/MCB.01091-14. Epub 2015 Jan 5.
3
Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function.溴结构域蛋白BRD4是自噬和溶酶体功能的转录抑制因子。
Mol Cell. 2017 May 18;66(4):517-532.e9. doi: 10.1016/j.molcel.2017.04.027.
4
Fasting-induced hormonal regulation of lysosomal function.禁食诱导的溶酶体功能的激素调节。
Cell Res. 2017 Jun;27(6):748-763. doi: 10.1038/cr.2017.45. Epub 2017 Apr 4.
5
Curcumin targets the TFEB-lysosome pathway for induction of autophagy.姜黄素靶向转录因子EB-溶酶体途径以诱导自噬。
Oncotarget. 2016 Nov 15;7(46):75659-75671. doi: 10.18632/oncotarget.12318.
6
Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism.自噬-溶酶体功能的转录调控驱动胰腺癌代谢。
Nature. 2015 Aug 20;524(7565):361-5. doi: 10.1038/nature14587. Epub 2015 Jul 13.
7
TFEB links autophagy to lysosomal biogenesis.TFEB 将自噬与溶酶体生物发生联系起来。
Science. 2011 Jun 17;332(6036):1429-33. doi: 10.1126/science.1204592. Epub 2011 May 26.
8
Nuclear miR-30b-5p suppresses TFEB-mediated lysosomal biogenesis and autophagy.核 miR-30b-5p 抑制 TFEB 介导的溶酶体生物发生和自噬。
Cell Death Differ. 2021 Jan;28(1):320-336. doi: 10.1038/s41418-020-0602-4. Epub 2020 Aug 6.
9
Methods to Monitor and Manipulate TFEB Activity During Autophagy.自噬过程中监测和调控转录因子EB（TFEB）活性的方法
Methods Enzymol. 2017;588:61-78. doi: 10.1016/bs.mie.2016.10.008. Epub 2016 Dec 16.
10
ZKSCAN3 is a master transcriptional repressor of autophagy.ZKSCAN3 是自噬作用的主要转录抑制因子。
Mol Cell. 2013 Apr 11;50(1):16-28. doi: 10.1016/j.molcel.2013.01.024. Epub 2013 Feb 21.
引用本文的文献
1
Autophagy: a molecular switch to regulate adipogenesis and lipolysis.自噬：调节脂肪生成和脂解的分子开关。
Mol Cell Biochem. 2022 Mar;477(3):727-742. doi: 10.1007/s11010-021-04324-w. Epub 2022 Jan 13.
2
Autophagy and the hallmarks of aging.自噬与衰老的特征。
Ageing Res Rev. 2021 Dec;72:101468. doi: 10.1016/j.arr.2021.101468. Epub 2021 Sep 24.
3
Contextualizing Autophagy during Gametogenesis and Preimplantation Embryonic Development.语境化自噬在配子发生和植入前胚胎发育中的作用。
Int J Mol Sci. 2021 Jun 12;22(12):6313. doi: 10.3390/ijms22126313.
4
Transcriptional coregualtor NUPR1 maintains tamoxifen resistance in breast cancer cells.转录共激活因子 NUPR1 维持乳腺癌细胞对他莫昔芬的耐药性。
Cell Death Dis. 2021 Feb 4;12(2):149. doi: 10.1038/s41419-021-03442-z.
5
ANXA6 suppresses the tumorigenesis of cervical cancer through autophagy induction.膜联蛋白A6通过诱导自噬抑制宫颈癌的肿瘤发生。
Clin Transl Med. 2020 Oct;10(6):e208. doi: 10.1002/ctm2.208.
6
Autophagy in Osteosarcoma.成骨肉瘤中的自噬作用。
Adv Exp Med Biol. 2020;1258:167-175. doi: 10.1007/978-3-030-43085-6_11.
7
Autophagy coupled to translation is required for long-term memory.自噬与翻译偶联是长期记忆所必需的。
Autophagy. 2021 Jul;17(7):1614-1635. doi: 10.1080/15548627.2020.1775393. Epub 2020 Jun 17.
8
Regulation of Expression of Autophagy Genes by Atg8a-Interacting Partners Sequoia, YL-1, and Sir2 in Drosophila.自噬基因表达的调控通过 Atg8a 相互作用伙伴 Sequoia、YL-1 和 Sir2 在果蝇中。
Cell Rep. 2020 May 26;31(8):107695. doi: 10.1016/j.celrep.2020.107695.
9
mA mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells.mA mRNA 甲基化通过调节睾丸间质细胞自噬来调控睾酮的合成。
Autophagy. 2021 Feb;17(2):457-475. doi: 10.1080/15548627.2020.1720431. Epub 2020 Jan 31.
10
Environmental Exposures and Asthma Development: Autophagy, Mitophagy, and Cellular Senescence.环境暴露与哮喘发病：自噬、线粒体自噬和细胞衰老。
Front Immunol. 2019 Nov 29;10:2787. doi: 10.3389/fimmu.2019.02787. eCollection 2019.
本文引用的文献
1
Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy.细胞核易位的ACSS2促进溶酶体生物合成和自噬的基因转录。
Mol Cell. 2017 Jun 1;66(5):684-697.e9. doi: 10.1016/j.molcel.2017.04.026. Epub 2017 May 25.
2
Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles.自噬的药理学调节：治疗潜力与持续存在的障碍
Nat Rev Drug Discov. 2017 Jul;16(7):487-511. doi: 10.1038/nrd.2017.22. Epub 2017 May 19.
3
Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function.溴结构域蛋白BRD4是自噬和溶酶体功能的转录抑制因子。
Mol Cell. 2017 May 18;66(4):517-532.e9. doi: 10.1016/j.molcel.2017.04.027.
4
Epigenetic Control of Autophagy: Nuclear Events Gain More Attention.自噬的表观遗传调控：核事件受到更多关注。
Mol Cell. 2017 Mar 2;65(5):781-785. doi: 10.1016/j.molcel.2016.12.027.
5
mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases.通过抑制 Akt 实现 mTORC1 独立的 TFEB 激活促进神经退行性贮积病中的细胞清除。
Nat Commun. 2017 Feb 6;8:14338. doi: 10.1038/ncomms14338.
6
Protein kinase C controls lysosome biogenesis independently of mTORC1.蛋白激酶 C 独立于 mTORC1 控制溶酶体生物发生。
Nat Cell Biol. 2016 Oct;18(10):1065-77. doi: 10.1038/ncb3407. Epub 2016 Sep 12.
7
Transcriptional regulation of mammalian autophagy at a glance.哺乳动物自噬的转录调控一览。
J Cell Sci. 2016 Aug 15;129(16):3059-66. doi: 10.1242/jcs.188920.
8
AMPK-SKP2-CARM1 signalling cascade in transcriptional regulation of autophagy.自噬转录调控中的AMPK-SKP2-CARM1信号级联反应
Nature. 2016 Jun 23;534(7608):553-7. doi: 10.1038/nature18014. Epub 2016 Jun 15.
9
TFEB at a glance.转录因子EB简介。
J Cell Sci. 2016 Jul 1;129(13):2475-81. doi: 10.1242/jcs.146365. Epub 2016 Jun 1.
10
Digesting the Expanding Mechanisms of Autophagy.解析自噬的扩展机制。
Trends Cell Biol. 2016 Aug;26(8):624-635. doi: 10.1016/j.tcb.2016.03.006. Epub 2016 Apr 2.
Zotero 插件