Institute of Science and Technology Austria, Klosterneuburg, Austria.
Nat Struct Mol Biol. 2017 Oct 5;24(10):800-808. doi: 10.1038/nsmb.3460.
The oxidative phosphorylation electron transport chain (OXPHOS-ETC) of the inner mitochondrial membrane is composed of five large protein complexes, named CI-CV. These complexes convert energy from the food we eat into ATP, a small molecule used to power a multitude of essential reactions throughout the cell. OXPHOS-ETC complexes are organized into supercomplexes (SCs) of defined stoichiometry: CI forms a supercomplex with CIII and CIV (SC I+III+IV, known as the respirasome), as well as with CIII alone (SC I+III). CIII forms a supercomplex with CIV (SC III+IV) and CV forms dimers (CV). Recent cryo-EM studies have revealed the structures of SC I+III+IV and SC I+III. Furthermore, recent work has shed light on the assembly and function of the SCs. Here we review and compare these recent studies and discuss how they have advanced our understanding of mitochondrial electron transport.
线粒体内膜的氧化磷酸化电子传递链（OXPHOS-ETC）由五个大型蛋白质复合物组成，分别命名为 CI-CV。这些复合物将我们所吃食物中的能量转化为 ATP，一种小分子，用于为细胞内的众多基本反应提供动力。OXPHOS-ETC 复合物组织成具有明确计量比的超复合物（SCs）：CI 与 CIII 和 CIV 形成超复合物（SC I+III+IV，也称为呼吸体），并与 CIII 单独形成超复合物（SC I+III）。CIII 与 CIV 形成超复合物（SC III+IV），CV 形成二聚体（CV）。最近的冷冻电镜研究揭示了 SC I+III+IV 和 SC I+III 的结构。此外，最近的研究工作揭示了 SC 的组装和功能。在这里，我们回顾和比较这些最近的研究，并讨论它们如何提高我们对线粒体电子传递的理解。
