Lason W, Simpson J N, McGinty J F
Department of Anatomy, School of Medicine, East Carolina University, Greenville, NC 27858-4354.
Neurosci Lett. 1988 Apr 22;87(1-2):23-8. doi: 10.1016/0304-3940(88)90139-5.
In rats, the seizures induced by systemic kainic acid (KA) are followed by extensive neuronal damage, notably in the hippocampal region. We report that the specific N-methyl-D-aspartate (NMDA) receptor antagonist, D-(-)-aminophosphonovalerate (D(-)APV), given i.c.v. prior to or 2 h after i.p. KA injection markedly protected CA1 but not other hippocampal neurons against degeneration. In contrast, D(-)APV had no effect on KA-induced wet dog shakes or on behavioral seizures. We conclude that NMDA receptors participate in the neurotoxic but not in the behavioral effects of systemic KA.
在大鼠中，全身性给予海藻酸（KA）诱发癫痫发作后会出现广泛的神经元损伤，尤其是在海马区。我们报告，特异性N-甲基-D-天冬氨酸（NMDA）受体拮抗剂D-（-）-氨基磷酸戊酸（D（-）APV），在腹腔注射KA之前或之后2小时经脑室内给予，能显著保护CA1区神经元免于退变，但对海马区其他神经元无保护作用。相比之下，D（-）APV对KA诱发的湿狗样抖动或行为性癫痫发作没有影响。我们得出结论，NMDA受体参与全身性KA的神经毒性作用，但不参与其行为学效应。
