Bowman Alex S, Mehta Mili, Lerebours Nadal Leonel, Halpern Mina, Nicholas Stephen W, Amesty Silvia
1 College of Physicians and Surgeons, Columbia University , New York, New York.
2 Department of Epidemiology, Columbia University Mailman School of Public Health , New York, New York.
AIDS Patient Care STDS. 2017 Oct;31(10):407-412. doi: 10.1089/apc.2017.0118.
Innovative empirical frameworks to evaluate progress in efforts addressing HIV treatment and prevention barriers in resource-limited areas are sorely needed to achieve the UNAIDS 90-90-90 goal (90% diagnosed, 90% on treatment, and 90% virally suppressed). A triadic implementation framework (TIF) is a comprehensive conceptual tool for (1) monitoring attrition, (2) evaluating operational programs, and (3) measuring the impact of specific implementation goals within the care continuum. TIF will assess the effects of enhanced programs on adherence and virologic suppression within the HIV care continuum at a regional clinic in the Dominican Republic (Clínica de Familia La Romana [CFLR]) and its program serving high-risk, migratory batey (sugarcane cultivation) communities. A retrospective cohort study completed during 2015 collected deidentified data from a CFLR chart review of adult HIV patients diagnosed in 2013. The results were quantitatively analyzed and compared to 2011 cohort data. In 2013, 310 patients were diagnosed HIV positive. The results demonstrated 73% enrolling in care, 28% adhering to care, and 16% achieving viral load suppression. Engagement increased across all steps of the care continuum compared to a 2011 cohort, culminating in a significant increase in undetectable viral load from 4% to 16% (p < 0.001). The batey program showed significant increases in patient enrollment compared to the 2011 cohort (p < 0.001). Meeting the UNAIDS 90-90-90 goal requires enhanced services in high-burden, resource-limited regions. CFLR employs TIF to assess progress and programmatic areas in need of strengthening. Data suggest enhanced CFLR services improve outcomes. Given improvements, maintenance and expansion of similar programs are warranted to achieve the 90-90-90 goal.
为实现联合国艾滋病规划署的90-90-90目标(90%的感染者得到诊断、90%的确诊感染者接受治疗、90%接受治疗的感染者实现病毒抑制),迫切需要创新的实证框架来评估在资源有限地区应对艾滋病毒治疗和预防障碍方面所做努力的进展情况。三元实施框架(TIF)是一种全面的概念工具,用于(1)监测损耗情况、(2)评估运营项目以及(3)衡量护理连续过程中特定实施目标的影响。TIF将评估强化项目对多米尼加共和国一家地区诊所(罗马纳家庭诊所[CFLR])及其为高危流动甘蔗种植社区服务的项目中艾滋病毒护理连续过程中的依从性和病毒抑制情况的影响。2015年完成的一项回顾性队列研究从对2013年诊断的成年艾滋病毒患者的CFLR图表审查中收集了去标识化数据。对结果进行了定量分析,并与2011年队列数据进行了比较。2013年,310名患者被诊断为艾滋病毒阳性。结果显示,73%的患者登记接受护理,28%的患者坚持护理,16%的患者实现病毒载量抑制。与2011年队列相比,护理连续过程各阶段的参与度均有所提高,最终不可检测病毒载量从4%显著增至16%(p<0.001)。与2011年队列相比,甘蔗种植社区项目的患者登记人数显著增加(p<0.001)。要实现联合国艾滋病规划署的90-90-90目标,需要在高负担、资源有限地区加强服务。CFLR采用TIF来评估进展情况以及需要加强的项目领域。数据表明,CFLR强化服务可改善结果。鉴于已取得的进展,有必要维持和扩大类似项目以实现90-90-90目标。