Winter Meredith C, Halpern Mina, Brozovich Ava, Neu Natalie
J Int Assoc Provid AIDS Care. 2014 Jul-Aug;13(4):361-5. doi: 10.1177/2325957413514630.
Research has demonstrated that adherence to antiretroviral therapy (ART) results in lower rates of morbidity and mortality associated with HIV infection, yet adherence remains a challenge in resource-limited settings like the Dominican Republic. Clinica de Familia La Romana addressed this problem with an education-based adherence program for adult patients new to ART, and this retrospective cohort study aimed to evaluate the impact of this intervention. Appointment adherence and biological markers were assessed in cases and controls through 12 months. A total of 101 participants were included, with 61 controls and 40 cases. The baseline CD4 count was 162 and 157 cells/mm3 in controls and cases, respectively. Cases showed a 15-fold increase in CD4 count compared with a 2.5-fold increase in controls. Cases were more likelyto adhere to appointments with adherence rates of 86% versus 76% in controls. There was no difference between the rates of treatment abandonment, transfer of care, or death.
研究表明，坚持抗逆转录病毒疗法（ART）可降低与HIV感染相关的发病率和死亡率，但在多米尼加共和国等资源有限的环境中，坚持治疗仍然是一项挑战。罗马纳家庭诊所针对新接受ART治疗的成年患者开展了一项基于教育的坚持治疗项目来解决这一问题，这项回顾性队列研究旨在评估该干预措施的影响。通过12个月的时间对病例组和对照组的预约依从性和生物学指标进行了评估。总共纳入了101名参与者，其中61名作为对照组，40名作为病例组。对照组和病例组的基线CD4细胞计数分别为162个/mm³和157个/mm³。病例组的CD4细胞计数增加了15倍，而对照组仅增加了2.5倍。病例组更有可能坚持预约，依从率为86%，而对照组为76%。在治疗放弃率、护理转移率或死亡率方面没有差异。
