Department of Dermatology and Allergy Center, Odense Research Centre for Anaphylaxis (ORCA), Odense University Hospital, University of Southern Denmark, Odense, Denmark.
Hans Christian Andersen Children's Hospital, Odense University Hospital, University of Southern Denmark, Odense, Denmark.
Pediatr Allergy Immunol. 2017 Dec;28(8):776-783. doi: 10.1111/pai.12815.
Sensitization to both inhalant and food allergens has been shown to be risk factors for development of asthma and rhinoconjunctivitis (RC). However, few studies have addressed the role of transient or persistent IgE sensitization to specific allergens in early life for later development of allergic diseases. The aim of this study was to explore the association between transient and persistent sensitization in early life and the development of asthma and RC at 6 and 14 years.
The Danish Allergy Research Center (DARC) cohort is a prospective non-interventional birth cohort study comprising 562 children. For the purpose of this study, we examined a subgroup of the original cohort with specific IgE measured at, at least 3 of 4 follow-ups between 3 and 18 months of age (n = 366). Multiple logistic regression models were used to investigate the association between transient and persistent early-life sensitization to groups of and to individual allergens and asthma and RC at 6 and 14 years compared to a reference group with no sensitization.
Both transient early-life sensitization and persistent early-life sensitization to cow's milk or hen's egg proteins were associated with asthma (aOR 3.99[1.41-11.32] and 5.95[1.78-19.92]) and RC (aOR 2.94[1.19-7.28] and 6.18[1.86-20.53]) at 14 years, this association being driven mainly by sensitization to hen's egg. Transient early-life sensitization to house dust mite (HDM) had increased risk of asthma (aOR 3.80[1.17-12.41]) at 14 years.
Early transient IgE sensitization and persistent IgE sensitization to hen's egg were associated with asthma and RC at 14 years. Furthermore, sensitization to HDM was associated with asthma at 14 years.
已证实，对吸入性过敏原和食物过敏原的致敏作用是哮喘和鼻结膜炎（RC）发展的危险因素。然而，很少有研究涉及生命早期对特定过敏原的短暂或持续 IgE 致敏在以后发生过敏性疾病中的作用。本研究旨在探讨生命早期的短暂和持续致敏与 6 岁和 14 岁时哮喘和 RC 的发展之间的关系。
丹麦过敏研究中心（DARC）队列是一项前瞻性非干预性出生队列研究，共纳入 562 名儿童。为了进行本研究，我们检查了原始队列的一个亚组，这些儿童在 3 至 18 个月之间至少有 3 次随访时检测到特定 IgE（n=366）。使用多变量逻辑回归模型，研究了生命早期对组和单个过敏原的短暂和持续致敏与 6 岁和 14 岁时哮喘和 RC 的关系，与无致敏的参考组相比。
生命早期对牛奶或鸡蛋蛋白的短暂致敏和持续致敏均与哮喘（OR 3.99[1.41-11.32]和 5.95[1.78-19.92]）和 RC（OR 2.94[1.19-7.28]和 6.18[1.86-20.53]）相关，14 岁时这种相关性主要由鸡蛋致敏驱动。生命早期对屋尘螨（HDM）的短暂致敏与 14 岁时哮喘的风险增加相关（OR 3.80[1.17-12.41]）。
生命早期短暂 IgE 致敏和持续 IgE 致敏与 14 岁时的哮喘和 RC 相关。此外，HDM 致敏与 14 岁时的哮喘相关。
