In Situ Lipid Membrane Formation Triggered by Intramolecular Photoinduced Electron Transfer.

A major goal of synthetic biology is the development of rational methodologies to construct self-assembling non-natural membranes, which could enable the efficient fabrication of artificial cellular systems from purely synthetic components. However, spatiotemporal control of artificial membrane formation remains both challenging and limited in scope. Here, we describe a new methodology to promote biomimetic phospholipid membrane formation by the photochemical activation of a catalyst-sensitizer dyad via an intramolecular photoinduced electron-transfer process. Our results offer future opportunities to exert spatiotemporal control over artificial cellular constructs.