Takiyama Aki, Tanaka Toshiaki, Yamamoto Yoko, Hata Keisuke, Ishihara Soichiro, Nozawa Hiroaki, Kawai Kazushige, Kiyomatsu Tomomichi, Nishikawa Takeshi, Otani Kensuke, Sasaki Kazuhito, Watanabe Toshiaki
Department of Surgical Oncology, The University of Tokyo, Tokyo, Japan
Department of Surgical Oncology, The University of Tokyo, Tokyo, Japan.
Anticancer Res. 2017 Oct;37(10):5785-5790. doi: 10.21873/anticanres.12020.
BACKGROUND/AIM: Few studies have evaluated the risk of postoperative colorectal neoplasms stratified by the nature of primary colorectal cancer (CRC). In this study, we revealed it on the basis of the microsatellite (MS) status of primary CRC.
We retrospectively reviewed 338 patients with CRC and calculated the risk of neoplasms during postoperative surveillance colonoscopy in association with the MS status of primary CRC. A propensity score method was applied.
We identified a higher incidence of metachronous rectal neoplasms after the resection of MS stable CRC than MS instable CRC (adjusted HR 5.74, p=0.04). We also observed a higher incidence of colorectal tubular adenoma in patients with MSS CRC (adjusted hazard ratio 7.09, p<0.01) and a higher incidence of postoperative tubulovillous/villous adenoma in patients with MS instable CRC (adjusted HR=8.50, p=0.03).
The MS status of primary colorectal cancer influenced the risk of postoperative colorectal neoplasms.
背景/目的：很少有研究根据原发性结直肠癌（CRC）的性质对术后结直肠肿瘤的风险进行评估。在本研究中，我们基于原发性CRC的微卫星（MS）状态揭示了这一风险。
我们回顾性分析了338例CRC患者，并结合原发性CRC的MS状态计算了术后监测结肠镜检查期间肿瘤的风险。应用了倾向评分法。
我们发现，MS稳定的CRC切除术后异时性直肠肿瘤的发生率高于MS不稳定的CRC（校正风险比5.74，p = 0.04）。我们还观察到，MSS CRC患者的大肠管状腺瘤发生率较高（校正风险比7.09，p <0.01），而MS不稳定的CRC患者术后管状绒毛状/绒毛状腺瘤的发生率较高（校正风险比= 8.50，p = 0.03）。
原发性结直肠癌的MS状态影响术后结直肠肿瘤的风险。
