一种新型特异性非NMDA受体拮抗剂FG 9065可阻断大鼠大脑皮层中L-AP4诱发的去极化。
A new and specific non-NMDA receptor antagonist, FG 9065, blocks L-AP4-evoked depolarization in rat cerebral cortex.
作者信息
Sheardown M J
机构信息
A/S Ferrosan, Research Division, Soeborg, Denmark.
出版信息
Eur J Pharmacol. 1988 Apr 13;148(3):471-4. doi: 10.1016/0014-2999(88)90131-8.
L(+)-AP4 (2-amino-4-phosphonobutyrate) depolarized slices of rat cerebral cortex, when applied following a 2 min priming application of quisqualate. This response diminishes with time and is not seen after NMDA application. A new selective non-N-methyl-D-aspartate (NMDA) antagonist, 6-cyano-7-nitro-2,3-dihydroxyquinoxaline (FG 9065), inhibits the L(+)-AP4 depolarization. It is argued that the response is mediated indirectly by postsynaptic quisqualate receptors.
L(+)-AP4（2-氨基-4-膦酰丁酸）在应用2分钟的使君子酸盐引发剂后施加时，会使大鼠大脑皮层切片去极化。这种反应会随时间减弱，在应用NMDA后则不会出现。一种新的选择性非N-甲基-D-天冬氨酸（NMDA）拮抗剂6-氰基-7-硝基-2,3-二羟基喹喔啉（FG 9065）可抑制L(+)-AP4去极化。有观点认为，该反应是由突触后使君子酸盐受体间接介导的。
Zotero 插件