Office of Research, Endeavour College of Natural Health, Brisbane, 4006, Australia.
Medical Oncology Group of Australia, Clinical Oncology Society of Australia, Queensland Clinical Oncology Group, Brisbane, 4000, Australia.
Curr Oncol Rep. 2017 Oct 5;19(12):76. doi: 10.1007/s11912-017-0636-z.
The purpose of this mini review is to evaluate the literature on B vitamins and chemotherapy-induced peripheral neuropathy.
One hundred and five journal articles were evaluated and nine manuscripts were included. There was one in vitro, one was an animal and seven were human studies. The in vitro study was a safety study on vitamin B and oxaliplatin which was not directly related to CIPN. The animal study evaluated vitamin B on paclitaxel administration with positive results. The human studies varied using a vitamin B complex, vitamin B only and vitamin B. Chemotherapy-induced peripheral neuropathy (CIPN) continues to plague patients and the medical fraternity. Currently, there are still no conclusive protective or treatment options. B vitamins have been found to play a role in CIPN prevention, but further studies are required to ascertain possible protection and treatment options.
本次迷你综述旨在评估维生素 B 与化疗引起的周围神经病相关文献。
评估了 105 篇期刊文章，纳入了 9 篇文献。其中 1 篇为体外研究，1 篇为动物研究，7 篇为人的研究。体外研究是一项关于维生素 B 和奥沙利铂的安全性研究，与 CIPN 并无直接关系。动物研究评估了维生素 B 对紫杉醇给药的影响，结果呈阳性。人体研究则使用了维生素 B 复合物、维生素 B 单独用药和维生素 B 进行了不同的研究。化疗引起的周围神经病（CIPN）仍困扰着患者和医学界。目前，仍然没有明确的预防或治疗选择。维生素 B 已被发现对 CIPN 的预防具有一定作用，但仍需要进一步研究来确定可能的预防和治疗选择。
