Templeton A, Messinis I E, Baird D T
Fertil Steril. 1986 Dec;46(6):1113-7. doi: 10.1016/s0015-0282(16)49890-0.
The growth of ovarian follicles was assessed with the use of ultrasound in spontaneous cycles and in cycles stimulated with clomiphene citrate (CC) alone, CC plus pulsatile human menopausal gonadotropin, and CC plus pulsatile follicle-stimulating hormone (FSH). At the time of the onset of the luteinizing hormone surge (LH), the size of the leading follicle did not differ significantly between the spontaneous and the stimulated cycles, although it was larger in the CC/FSH cycles. During the two days before the LH surge onset, the growth rate was faster in the stimulated than the spontaneous cycles. It is suggested that despite the provocation of extremely high plasma-estradiol levels and multiple follicular development, the leading follicle in stimulated cycles ovulated at a size equal to or greater than that in spontaneous cycles. The reason for the higher follicle size in the CC/FSH cycles is, as yet, unclear.
在自然周期以及仅使用枸橼酸氯米芬（CC）、CC加脉冲式人绝经期促性腺激素、CC加脉冲式促卵泡激素（FSH）刺激的周期中，通过超声评估卵巢卵泡的生长情况。在促黄体生成素高峰（LH）开始时，尽管在CC/FSH周期中优势卵泡更大，但自然周期和刺激周期中优势卵泡的大小并无显著差异。在LH高峰开始前的两天内，刺激周期中的卵泡生长速度比自然周期更快。这表明，尽管刺激周期中出现了极高的血浆雌二醇水平和多个卵泡发育，但优势卵泡排卵时的大小等于或大于自然周期中的大小。CC/FSH周期中卵泡较大的原因尚不清楚。
