Petkov V D, Petkov V V, Stancheva S L
Institute of Physiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.
Gerontology. 1988;34(1-2):14-21. doi: 10.1159/000212925.
In experiments on 2-, 10- and 22-month-old rats it was found that the Bmax values of dopamine (DA2), serotonin (5-HT1) and enkephalin (Enk) receptors as well as the 5-HT level in the three brain regions (cortex, striatum and hypothalamus) decreased with age; the DA level in the brain cortex and striatum and the noradrenaline (NA) content in the brain cortex decreased, while the NA level in the striatum and the 5-hydroxyindolacetic acid (5-HIAA) level in the brain cortex and the striatum as well as the MAO-T and MAO-A activities in the three brain structures increased. It is suggested that these and other changes observed in brain neurotransmission are an important element in the neurochemical bases of the age-related changes in behavior.
在对2个月、10个月和22个月大的大鼠进行的实验中发现，三个脑区（皮层、纹状体和下丘脑）中多巴胺（DA2）、5-羟色胺（5-HT1）和脑啡肽（Enk）受体的Bmax值以及5-羟色胺水平随年龄增长而降低；大脑皮层和纹状体中的多巴胺水平以及大脑皮层中的去甲肾上腺素（NA）含量降低，而纹状体中的去甲肾上腺素水平以及大脑皮层和纹状体中的5-羟吲哚乙酸（5-HIAA）水平以及三个脑结构中的单胺氧化酶-T（MAO-T）和单胺氧化酶-A（MAO-A）活性增加。有人提出，在大脑神经传递中观察到的这些及其他变化是行为年龄相关变化的神经化学基础中的一个重要因素。
