Petkov V D, Stancheva S L, Petkov V V, Alova L G
Gen Pharmacol. 1987;18(4):397-401. doi: 10.1016/0306-3623(87)90097-8.
In experiments on 2-, 10- and 22-month old rats, it was found that essential age-related changes occurred in the brain level of biogenic monoamines (BMA) and in the monoamine oxidase (MAO) activity. In 22-month old rats the levels of dopamine (DA), noradrenaline (NA) and serotonin (5-HT) markedly declined in most of the brain structures studied. 5-HT significantly decreased in the frontal cortex, striatum and hypothalamus. DA decreased in the cerebral cortex and striatum and NA in the cerebral cortex. However, the NA level in the striatum of 22-month old rats was increased as compared to that in 2-month old rats. In most cases we observed significant differences (a decrease mainly) also in the level of BMA in 22-month old rats as compared to 10-month old rats. The differences, if any, in the BMA levels between 10- and 2-month old rats were less pronounced. The level of 5-hydroxyindole acetic acid (5-HIAA) in the cerebral cortex and striatum of 22-month old rats was significantly higher as compared to that in 2-month old rats. The MAO-T and MAO-A activities in the brain structures studied were significantly higher in 22-month old rats as compared to those in 2-month old rats. The possibility that the age-related changes in brain neurotransmission might be an important element in the neurochemical basis of some behavioral changes in advanced age is considered.
在对2个月、10个月和22个月大的大鼠进行的实验中，发现生物源性单胺（BMA）的脑水平和单胺氧化酶（MAO）活性发生了与年龄相关的重要变化。在22个月大的大鼠中，所研究的大多数脑结构中多巴胺（DA）、去甲肾上腺素（NA）和血清素（5-HT）的水平显著下降。额叶皮质、纹状体和下丘脑中的5-HT显著降低。大脑皮质和纹状体中的DA降低，大脑皮质中的NA降低。然而，与2个月大的大鼠相比，22个月大的大鼠纹状体中的NA水平有所升高。在大多数情况下，我们还观察到，与10个月大的大鼠相比，22个月大的大鼠BMA水平也存在显著差异（主要是降低）。10个月和2个月大的大鼠之间BMA水平的差异（如果有的话）不太明显。与2个月大的大鼠相比，22个月大的大鼠大脑皮质和纹状体中5-羟吲哚乙酸（5-HIAA）的水平显著更高。与2个月大的大鼠相比，22个月大的大鼠所研究脑结构中的MAO-T和MAO-A活性显著更高。研究认为，脑内神经传递的年龄相关变化可能是老年某些行为变化神经化学基础中的一个重要因素。
