甲状腺癌差异表达基因的综合特征分析。
Comprehensive characterization of differentially expressed genes in thyroid cancer.
机构信息
Department of Nuclear Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, 310016 Hangzhou, Zhejiang Province, China.
Department of Internal Neurology, Hangzhou Seventh People's Hospital, 310000 Hangzhou, Zhejiang Province, China.
出版信息
Future Oncol. 2017 Oct;13(24):2159-2169. doi: 10.2217/fon-2017-0168. Epub 2017 Oct 6.
AIM
To explore the patterns of gene expression and functionally characterize the differentially expressed genes (DEGs) in thyroid cancer.
METHODS
DEGs were determined between 57 paired thyroid cancer and noncancerous tissues using DESeq2. Subsequently, the main functions of the DEGs were studied by a variety of analyses.
RESULTS
We identified a cohort of 752 upregulated and 309 downregulated DEGs in thyroid cancer. Several hub DEGs were found in the protein-protein interaction networks. We also revealed a set of DEGs that were dysmethylated, involved in copy number variations and associated with clinical features in thyroid cancer.
CONCLUSION
These results provide some novel findings on DEGs in thyroid cancer, which will be useful to guide further investigation and target therapy for this disease. [Formula: see text].
目的
探讨甲状腺癌中基因表达模式及差异表达基因（DEGs）的功能特征。
方法
使用 DESeq2 在 57 对甲状腺癌和非癌组织中确定 DEGs。随后，通过多种分析研究 DEGs 的主要功能。
结果
我们在甲状腺癌中鉴定出了 752 个上调和 309 个下调的 DEGs。在蛋白质-蛋白质相互作用网络中发现了几个关键的 DEGs。我们还揭示了一组在甲状腺癌中出现异常甲基化、涉及拷贝数变异并与临床特征相关的 DEGs。
结论
这些结果为甲状腺癌中的 DEGs 提供了一些新的发现，这将有助于指导针对该疾病的进一步研究和靶向治疗。
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