aDepartment of Health Psychology, University of Miami, Coral Gables, Florida bBehavioral Medicine Research Center cDivision of Endocrinology, Diabetes and Metabolism, Miller School of Medicine, University of Miami, Miami, Florida, USA.
Curr Opin HIV AIDS. 2017 Nov;12(6):528-533. doi: 10.1097/COH.0000000000000408.
The increasing prevalence of cardiovascular disease comorbidity in persons infected with the HIV has become a global concern. The electrocardiogram (ECG) is increasingly being utilized to provide clinically relevant information regarding cardiac arrhythmias and cardio-autonomic dysfunction. The purpose of this review is to summarize the latest research comparing QT and R-to-R interval length as a function of HIV+ status or antiretroviral therapy (ART) regimen.
Prolongation of the corrected QTc interval may be acquired in HIV+ ART-naive individuals, exacerbated by various classes of ART drugs, and is generally predictive of lethal cardiac arrhythmias, with effects observed from childhood to adulthood. Recent literature also suggests the trend of lower heart rate variability in HIV is indicative of cardiorespiratory and inflammatory-immune dysfunction.
These emergent studies support the clinical relevance of the ECG across the age and HIV disease spectrum. Furthermore, the reported findings have implications for the management of cardiovascular and chronic inflammatory disease comorbidity in persons living with HIV.
在感染 HIV 的人群中心血管疾病合并症的患病率不断增加，已成为全球关注的问题。心电图（ECG）越来越多地被用于提供有关心律失常和心脏自主神经功能障碍的临床相关信息。本综述的目的是总结最新的研究，比较 QT 和 R-R 间期长度作为 HIV+状态或抗逆转录病毒治疗（ART）方案的函数。
未经 ART 治疗的 HIV+个体可能会获得校正的 QTc 间期延长，各种 ART 药物会加重这种情况，并且通常可预测致命性心律失常，从儿童期到成年期都可观察到这种影响。最近的文献还表明，HIV 患者的心率变异性较低表明心肺和炎症免疫功能障碍。
这些新出现的研究支持心电图在整个年龄和 HIV 疾病谱中的临床相关性。此外，报告的发现对管理 HIV 感染者的心血管和慢性炎症性疾病合并症具有重要意义。
