Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, USA.
Department of Psychology, University of Georgia, Athens, GA, USA.
AIDS Care. 2021 May;33(5):585-593. doi: 10.1080/09540121.2020.1761518. Epub 2020 May 13.
The syndemic conditions of low education, childhood maltreatment, depression, HIV, alcohol and cocaine use, and obesity have been established as independent risk factors for cardiovascular risk, but research examining the association between syndemic conditions and cardiovascular risk in high-risk populations is lacking. A total of = 503 participants underwent an ultrasound of the carotid artery to assess for atherosclerotic plaque. Participants, HIV-infected ( = 202) and HIV-uninfected ( = 301) with and without a history of cocaine use, were a mean age of 36.13 years (SD = 9.51); 50% were male, and 62% were African-American. Each syndemic condition was associated with 8% greater odds of atherosclerotic plaque (OR = 1.08), 9% greater odds of systolic blood pressure (OR = 1.09), and 10% greater odds of diastolic blood pressure (OR = 1.10). Multilevel research, interventions, and public policy initiatives are needed to activate stakeholders at each level to maximize their impact at a community level among populations with high rates of syndemic conditions.
低教育水平、儿童期虐待、抑郁、艾滋病毒、酒精和可卡因使用以及肥胖等综合征条件已被确定为心血管风险的独立危险因素，但缺乏研究检查高风险人群中综合征条件与心血管风险之间的关联。共有 503 名参与者接受了颈动脉超声检查，以评估动脉粥样硬化斑块。参与者包括艾滋病毒感染者（202 名）和艾滋病毒未感染者（301 名），以及有和没有可卡因使用史的参与者，平均年龄为 36.13 岁（标准差=9.51）；50%为男性，62%为非裔美国人。每种综合征条件与动脉粥样硬化斑块的发生几率增加 8%（OR=1.08）、收缩压的发生几率增加 9%（OR=1.09）和舒张压的发生几率增加 10%（OR=1.10）相关。需要多层次的研究、干预措施和公共政策倡议，以激活各级利益相关者，在高综合征条件人群中最大限度地发挥其在社区层面的影响。
