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颈椎硬膜外镇痛并发硬膜外脓肿:一例病例报告及文献综述

Cervical epidural analgesia complicated by epidural abscess: A case report and literature review.

作者信息

Zhang Jun-Hui, Wang Zhi-Li, Wan Li

机构信息

903 Hospital, Jiangyou City, Sichuan Province The Second Affiliated Hospital, State Key Clinical Specialty in Pain Medicine, Guangzhou Medical University, Guangzhou, Guangdong, P.R. China.

出版信息

Medicine (Baltimore). 2017 Oct;96(40):e7789. doi: 10.1097/MD.0000000000007789.

DOI:10.1097/MD.0000000000007789
PMID:28984753
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5737989/
Abstract

RATIONALE

Spinal epidural abscess is an uncommon complication in clinical practice. If the abscess is large enough, the patient will rapidly develop neurologic signs of spinal injury, and urgent neurosurgical intervention may be required.

PATIENT CONCERNS

Rapid and correct diagnosis and treatment is important for spinal epidural abscess complication.

DIAGNOSES

This report describes a cervical epidural abscess (CEA) caused by epidural analgesia, wherein the patient was punctured twice. A CEA was suspected based on the patient's significant neck pain and elevated white blood cell and neutrophil counts. A CEA from C6 to T8 was confirmed by magnetic resonance imaging scan.

INTERVENTIONS

The patient was treated with a combination of intravenous vancomycin and imipenem/cilastatin for more than 4 weeks.

OUTCOMES

After more than 2 weeks of intensive antibiotic treatment, the epidural abscess gradually diminished in size, the white blood cell count, neutrophil count, hyperallergic C-reactive protein (CRP), and general CRP decreased, and the patient's neck and back pain resolved. After more than 4 weeks of anti-inflammation therapy, the epidural abscess was completely absorbed, and there was no relapse during the 3-month follow-up period.

LESSONS

Although an effective combination of intravenous antibiotics can cure an epidural abscess, caution is warranted when performing epidural steroid injections in immunocompromised patients.

摘要

原理

脊柱硬膜外脓肿在临床实践中是一种罕见的并发症。如果脓肿足够大,患者将迅速出现脊髓损伤的神经体征,可能需要紧急神经外科干预。

患者关注

快速正确的诊断和治疗对于脊柱硬膜外脓肿并发症很重要。

诊断

本报告描述了一例由硬膜外镇痛引起的颈椎硬膜外脓肿(CEA),该患者接受了两次穿刺。基于患者严重的颈部疼痛以及白细胞和中性粒细胞计数升高,怀疑为CEA。磁共振成像扫描证实了从C6到T8的CEA。

干预措施

患者接受了静脉注射万古霉素和亚胺培南/西司他丁联合治疗超过4周。

结果

经过2周多的强化抗生素治疗后,硬膜外脓肿逐渐缩小,白细胞计数、中性粒细胞计数、超敏C反应蛋白(CRP)和总CRP均下降,患者的颈部和背部疼痛缓解。经过4周多的抗炎治疗后,硬膜外脓肿完全吸收,在3个月的随访期内无复发。

经验教训

尽管静脉使用抗生素的有效联合可以治愈硬膜外脓肿,但在免疫功能低下的患者中进行硬膜外类固醇注射时仍需谨慎。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92a1/5737989/2804473755af/medi-96-e7789-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92a1/5737989/901e4d5aca6a/medi-96-e7789-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92a1/5737989/5c1da9fd2bff/medi-96-e7789-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92a1/5737989/1ba58e17470d/medi-96-e7789-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92a1/5737989/2804473755af/medi-96-e7789-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92a1/5737989/901e4d5aca6a/medi-96-e7789-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92a1/5737989/5c1da9fd2bff/medi-96-e7789-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92a1/5737989/1ba58e17470d/medi-96-e7789-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92a1/5737989/2804473755af/medi-96-e7789-g004.jpg

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